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. Author manuscript; available in PMC: 2020 May 18.
Published in final edited form as: Nat Genet. 2019 Nov 18;51(12):1670–1678. doi: 10.1038/s41588-019-0512-x

Figure 4 ∣. Genetic risk prediction accuracy in EAS from EAS or EUR training data.

Figure 4 ∣

Polygenic risk scores were computed with GWAS summary statistics from EAS and EUR populations as training sets. EAS risk alleles and weights were computed with a leave-one-out meta-analysis approach across the 13 stage 1 samples. Error bars indicate the 95% confidence interval. LD panel for clumping is from EUR and EAS 1000 Genomes Phase 3 samples. a, Case/control variance explained in EAS samples by variants from EAS and EUR training data with a P-value more significant than the threshold. b, Case/control variance explained by the n most significant independent variants. a-b, For EAS stage 1: 13,305 cases and 16,244 controls; For EUR 33,640 cases and 43,456 controls.