Table 1 ∣.
Genome-wide significant loci in the East Asian populations.
| Stage 1 | Stage 2 | Combined | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SNP | Chr | BP | AL | P | OR | P | OR | P | OR |
| rs4660761 | 1 | 44440146 | A/G | 3.6E-06 | 0.91 | 3.53E-04 | 0.92 | 5.08E-09 | 0.91 |
| rs848293 | 2 | 58382490 | A/G | 3.7E-10 | 0.90 | 3.10E-09 | 0.87 | 9.87E-18 | 0.89 |
| rs17592552 | 2 | 201176071 | T/C | 8.4E-10 | 0.86 | 2.68E-05 | 0.89 | 1.50E-13 | 0.88 |
| rs2073499 | 3 | 50374293 | A/G | 1.1E-09 | 0.89 | 2.14E-05 | 0.91 | 1.33E-13 | 0.90 |
| rs76442143 | 3 | 51043599 | T/C | 6.9E-09 | 1.14 | 1.03E-02 | 1.08 | 6.40E-10 | 1.12 |
| rs10935182 | 3 | 136137422 | A/G | 1.3E-06 | 0.90 | 1.33E-04 | 0.90 | 7.08E-10 | 0.90 |
| rs4856763 | 3 | 161831675 | A/G | 3.9E-06 | 0.92 | 8.54E-06 | 0.91 | 1.73E-10 | 0.92 |
| rs13096176 | 3 | 180752138 | T/C | 3.1E-07 | 0.88 | 2.21E-03 | 0.90 | 3.35E-09 | 0.89 |
| rs6832165 | 4 | 24270210 | C/G | 3.7E-08 | 1.12 | 3.70E-01 | 1.08 | 2.79E-08 | 1.12 |
| rs13142920 | 4 | 176728614 | A/C | 9.5E-05 | 0.93 | 5.85E-06 | 0.89 | 4.85E-09 | 0.92 |
| rs4479913 | 6 | 165075210 | A/G | 3.6E-07 | 1.13 | 9.98E-05 | 1.12 | 1.53E-10 | 1.12 |
| rs320696 | 7 | 137047137 | A/C | 5.5E-08 | 0.90 | 1.07E-02 | 0.93 | 2.81E-09 | 0.91 |
| rs11986274 | 8 | 38259481 | T/C | 5.1E-04 | 1.07 | 2.73E-06 | 1.11 | 1.44E-08 | 1.08 |
| rs2612614 | 8 | 65310836 | A/G | 2.2E-08 | 1.14 | 4.51E-02 | 1.06 | 1.62E-08 | 1.11 |
| rs4147157 | 10 | 104536360 | A/G | 6.6E-10 | 0.90 | 3.87E-07 | 0.89 | 1.32E-15 | 0.89 |
| rs10861879 | 12 | 108609634 | A/G | 4.8E-07 | 1.09 | 5.00E-03 | 1.07 | 1.18E-08 | 1.08 |
| rs1984658 | 12 | 123483426 | A/G | 5.1E-11 | 0.89 | 2.14E-04 | 0.92 | 8.62E-14 | 0.90 |
| rs9567393 | 13 | 32763757 | A/G | 3.5E-08 | 1.11 | 4.37E-03 | 1.07 | 1.13E-09 | 1.09 |
| rs9890128 | 17 | 1273646 | T/C | 3.5E-08 | 0.90 | 2.44E-02 | 0.91 | 2.61E-09 | 0.90 |
| rs11665111 | 18 | 77622996 | T/C | 5.2E-06 | 1.08 | 6.89E-04 | 1.09 | 1.46E-08 | 1.09 |
| rs55642704 | 18 | 77688124 | T/C | 1.1E-06 | 1.09 | 7.11E-06 | 1.10 | 3.76E-11 | 1.09 |
BP, genomic position in HG19; AL, reference and non-reference alleles; OR, odds ratio; P, P-value. n (EAS stage 1) = 13,305 cases, 16,244 controls; n (EAS stage 1+2) = 22,778 cases, 35,362 controls. Fixed effect inverse variance meta-analysis was utilized to generate P-values.