Figure 4.

SOST KO mice presented an increase in activation of osteogenesis and a decrease in activation of osteoclasts. (a) The Masson trichrome staining revealed that the mineralization in the subchondral area was more intense in the OA knees of SOST KO mice, when compared to that of WT mice. (b, c) The TRAP-positive cells were identified as red multinuclear cells near the subchondral trabecular bone. The TRAP-positive cell number in OA knees of SOST KO mice was comparatively lesser than that of WT mice. There was no significant difference between the sham-operation groups of SOST KO and WT mice (^∗P < 0.05; the data were presented as mean ± SD).