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. 2019 Nov 11;2019:7850154. doi: 10.1155/2019/7850154

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Copyright © 2019 Qiu-Yan Zhang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

SCM-198 improved bEnd.3 cell antioxidative capacity in vitro. SCM-198 exhibited antioxidant abilities and improved the cell viability of bEnd.3. (a) Cell viability, evaluated by an MTT assay, was significantly reduced after OGD/R injury exposure, while 1 μM and 10 μM of SCM-198 could increase cell viability. (b) MDA level of the SCM-198 group was remarkably decreased as compared to the OGD/R group. (c) SCM-198 could predominantly increase intercellular antioxidative capacity by restoring the CAT activity. (d) SCM-198 obviously improved the expression of SOD1. (e) SCM-198 reduced the cell apoptosis in bEnd.3. OGD/R-induced cell apoptosis was determined by TUNEL staining. (f) The result showed that OGD/R obviously increased the apoptosis ratio, whereas treatment with SCM-198 reduced cell apoptosis. Values are expressed as mean ± SD. ^#p < 0.05 versus control group, ^∗p < 0.05 versus OGD group (n = 3).