Skip to main content
. 2019 Nov 11;2019:7850154. doi: 10.1155/2019/7850154

Figure 4.

Figure 4

SCM-198 protected neurons via modulating BMECs in BMEC/neuron coculture system. bEnd.3 treated with SCM-198 and cocultured with SH-SY5Y exhibited protection against OGD/R injury by improving the cell viability and the antioxidative ability. (a) Treatment with SCM-198, especially 1 μM and 10 μM, increased bEnd.3 cell viability in OGD/R irritation. (b) SCM-198 could reduce the LDH leakage in SH-SY5Y cells. (c) SCM-198 decreased the production of MDA in SH-SY5Y cells after OGD/R injury. (d) SCM-198 increased the activity of CAT. (e) SCM-198 reduced cell apoptosis in SH-SY5Y. OGD/R-induced cell apoptosis was determined by TUNEL staining; the result showed that OGD/R obviously increased the number of apoptosis, whereas treatment with SCM-198 reduced cell apoptosis. (f) The quantitative analysis of apoptotic cells was calculated. Values are expressed as mean ± SD. #p < 0.05 versus control group, ∗p < 0.05 versus OGD group (n = 3).