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. 2019 Nov 11;2019:7850154. doi: 10.1155/2019/7850154

Figure 5.

Figure 5

The mechanism of SCM-198 inhibited apoptosis induced by OGD/R. (a–c) SCM-198 regulated the expression of apoptosis-related protein in bEnd.3. OGD/R increased the expression of Bax. OGD/R also decreased the expression of Bcl-2 and Bcl-xl, while SCM-198 could markedly improve the expression of Bcl-2 and Bcl-xl and reduce Bax expression. (d, e) SCM-198 regulated the expression of apoptosis-related protein in SH-SY5Ycells. OGD/R increased the expression of Bax and decreased the expression of Bcl-2 and Bcl-xl, while SCM-198 could obviously improve the expression of Bcl-2 and Bcl-xl and reduce Bax expression. (g–i) SCM-198 regulated the expression of p-STAT3, NOX4, and p-Akt in bEnd.3. SCM-198 protected against apoptosis through improving the level of p-STAT3 and inhibiting the expression of NOX4, then modulated p-Akt. Values are expressed as mean ± SD. #p < 0.05 versus control group, ∗p < 0.05 versus OGD group (n = 3).