Table 2. The KEGG pathway of the potential target genes.
The KEGG pathway were analyzed by the predicted target genes of 14 differentially expressed miRNAs.
| Term | Count | p Value | Genes |
|---|---|---|---|
| Pathways in cancer | 54 | 4.13E−05 | E2F2, ADCY1, FGF7, PPARG, LPAR4, FOXO1, LPAR1, PTEN, CCNE1, MAX, FOS, RALA, PLCB1, AKT3, PTGER4, ROCK2, RUNX1T1, LEF1, STK4, VEGFC, EP300, CRKL, HIF1A, GNB2, GNAQ, JUN, MAPK3, MAPK9, GNAS, WNT5A, GNAI3, BCL2L1, TCF7L2, IGF1R, RAC1, RUNX1, TRAF3, AXIN1, COL4A3, BMP2, MAP2K1, CBL, SMAD3, RAF1, HGF, FZD5, KITL, FZD4, FZD7, NRAS, CBLB, CDKN1A, LAMA5, GNG10 |
| PI3K-Akt signaling pathway | 42 | 0.004263 | CRTC2, FGF7, PPP2R5A, CSF1, LPAR4, BCL2L1, LPAR1, PTEN, CCNE1, IGF1R, COMP, PPP2CA, RAC1, CREB3L1, ANGPT1, PDGFD, COL11A1, INSR, PPP2R2D, AKT3, COL4A3, SGK1, MAP2K1, ITGA1, RAF1, HGF, ITGA4, KITL, COL5A2, IL6RA, NRAS, VEGFC, CDKN1A, GNB2, CCND2, LAMA5, GNG10, MAPK3, YWHAQ, EFNA4, COL24A1, IL2 |
| MAPK signaling pathway | 37 | 2.07E−04 | IL1R1, FGF7, TNF, MRAS, DUSP10, CACNB2, CACNB4, MAX, FOS, MAP3K2, MAP3K1, RAC1, MAP3K8, PPP3CA, MAP2K6, AKT3, NFATC1, NTF3, MAP2K1, TAOK1, NF1, MAP2K4, RAF1, STK4, NRAS, CRKL, MAPK12, DUSP1, RPS6KA2, JUN, MAPK3, MAPK9, RAP1B, DUSP8, GADD45A, CACNA1D, DUSP6 |
| HTLV-I infection | 35 | 0.004332 | WNT5A, CRTC2, E2F2, IL1R1, ADCY1, TNF, MRAS, ITGB2, BCL2L1, MYBL2, MSX2, FOS, MAP3K1, PPP3CA, AKT3, TBPL1, NFATC1, KAT2B, MAP2K4, SMAD3, FZD5, FZD4, FZD7, NRAS, CDKN1A, SLC25A31, MSX1, ATF3, EP300, MAD2L1, CCND2, ETS1, JUN, ETS2, IL2 |
| Proteoglycans in cancer | 34 | 2.73E-05 | WNT5A, CAV2, CAV1, TNF, MRAS, CAMK2G, LUM, SDC4, HOXD10, IQGAP1, SDC2, IGF1R, ANK2, RAC1, FRS2, CAMK2A, AKT3, MAP2K1, ROCK2, CBL, RAF1, HGF, FZD5, DDX5, FZD4, PPP1CB, FZD7, NRAS, CDKN1A, CBLB, HIF1A, MAPK12, MAPK3, HBEGF |
| Focal adhesion | 34 | 4.10E−05 | CAV2, CAV1, PTEN, VCL, IGF1R, PAK7, ARHGAP5, PAK4, COMP, RAC1, PDGFD, COL11A1, AKT3, COL4A3, VAV3, ACTN4, MAP2K1, ROCK2, ITGA1, RAF1, ACTN1, HGF, ITGA4, COL5A2, PPP1CB, VEGFC, CRKL, CCND2, LAMA5, JUN, MAPK3, MAPK9, RAP1B, COL24A1 |
| Rap1 signaling pathway | 33 | 1.86E−04 | ADCY1, FGF7, GNAI3, CSF1, MRAS, LPAR4, ITGB2, LPAR1, IGF1R, CNR1, RAC1, RALA, ANGPT1, PDGFD, PLCB1, INSR, AKT3, MAP2K6, MAP2K1, RAF1, HGF, KITL, DOCK4, NRAS, VEGFC, CRKL, GNAQ, MAPK12, ID1, MAPK3, GNAS, RAP1B, EFNA4 |
| Ras signaling pathway | 31 | 0.002606 | FGF7, CSF1, MRAS, ARF6, BCL2L1, IGF1R, PAK7, PAK4, RAC1, RALA, ANGPT1, PDGFD, INSR, AKT3, MAP2K1, NF1, RAF1, HGF, STK4, KITL, NRAS, VEGFC, GNB2, ETS1, GNG10, ETS2, MAPK3, MAPK9, PLA2G6, RAP1B, EFNA4 |
| cAMP signaling pathway | 30 | 4.80E−04 | ADCY1, GNAI3, CAMK2G, PDE3B, SOX9, FOS, RAC1, PDE4B, CREB3L1, SUCNR1, CAMK2A, AKT3, NFATC1, VAV3, MAP2K1, ROCK2, HTR4, RAF1, CFTR, GRIA4, ATP1A2, PPP1CB, EP300, GRIA2, JUN, MAPK3, MAPK9, GNAS, RAP1B, CACNA1D |
| Endocytosis | 29 | 0.082734 | CAV2, CAV1, CHMP4B, CAPZA2, SNX2, ARF6, SNX4, EEA1, CLTC, AMPH, IGF1R, ARPC2, SH3GLB1, WWP1, SPG20, DNAJC6, VPS4A, WIPF1, IQSEC2, CBL, KIF5C, PSD3, SMAD3, A230046K03RIK, ARPC1A, CBLB, RAB35, WASL, RAB10 |
| Oxytocin signaling pathway | 28 | 6.06E−05 | ADCY1, GNAI3, CAMK2G, CACNB2, CACNB4, KCNJ12, KCNJ14, FOS, PPP3CA, PLCB1, CAMK2A, NFATC1, MAP2K1, ROCK2, PRKAB2, PRKAB1, RAF1, PPP1CB, KCNJ5, CD38, NRAS, CDKN1A, GNAQ, JUN, MAPK3, GNAS, GUCY1B3, CACNA1D |
| Regulation of actin cytoskeleton | 27 | 0.012774 | FGF7, MRAS, IQGAP3, ITGB2, IQGAP1, VCL, PAK7, ARPC2, PAK4, RAC1, PDGFD, VAV3, MAP2K1, ACTN4, ROCK2, ITGA1, ACTN1, RAF1, ITGA4, PPP1CB, ARPC1A, NRAS, CRKL, MAPK3, CYFIP1, WASL, PIP4K2B |
| Dopaminergic synapse | 26 | 2.50E−05 | GNAI3, PPP2R5A, CAMK2G, KIF5C, MAOB, GRIA4, PPP1CB, KCNJ5, FOS, GNAQ, GRIA2, GNB2, MAPK12, PPP2CA, GNG10, SLC18A2, CREB3L1, MAPK9, GNAS, PPP3CA, PLCB1, CACNA1D, CAMK2A, CLOCK, AKT3, PPP2R2D |
| FoxO signaling pathway | 26 | 2.50E−05 | SGK1, MAP2K1, PRKAB2, PRKAB1, FOXO1, SMAD3, RAF1, HOMER1, SIRT1, STK4, PTEN, IL10, NRAS, IGF1R, TNFSF10, PLK4, CDKN1A, EP300, MAPK12, CCND2, MAPK3, MAPK9, KLF2, GADD45A, INSR, AKT3 |
| Signaling pathways regulating pluripotency of stem cells | 26 | 4.19E−05 | WNT5A, BMI1, MEIS1, ACVR1C, ACVR1B, IGF1R, AKT3, AXIN1, BMP2, MAP2K1, MYF5, SMAD5, SMAD3, RAF1, FZD5, FZD4, FZD7, NRAS, ACVR2A, MAPK12, ID1, MAPK3, ID4, BMPR1B, ZFHX3, BMPR1A |
| Axon guidance | 25 | 3.80E−05 | GNAI3, PLXNA2, EPHB2, SEMA5A, PAK7, UNC5B, SEMA3F, PAK4, SEMA3E, RAC1, PPP3CA, SEMA3A, LRRC4, ROCK2, NTNG1, SLIT2, SLIT3, NCK2, EPHA4, SEMA6A, NRAS, EPHA7, RND1, MAPK3, EFNA4 |
| Hippo signaling pathway | 25 | 4.73E−04 | WNT5A, BTRC, GDF6, ITGB2, TCF7L2, LATS2, CTGF, PPP2CA, DLG3, FBXW11, PPP2R2D, AXIN1, BMP2, SMAD3, LEF1, FZD5, SNAI2, FZD4, PPP1CB, FZD7, ID1, CCND2, YWHAQ, BMPR1B, BMPR1A |
| Wnt signaling pathway | 24 | 4.22E−04 | WNT5A, ROCK2, CAMK2G, BTRC, LEF1, FZD5, DAAM2, TCF7L2, FZD4, FZD7, EP300, SFRP1, CCND2, JUN, RAC1, MAPK9, WIF1, PPP3CA, RUVBL1, PLCB1, CAMK2A, FBXW11, AXIN1, NFATC1 |
| Transcriptional misregulation in cancer | 24 | 0.003952 | BMI1, CCNT2, NFKBIZ, LDB1, PPARG, RUNX1T1, FOXO1, TSPAN7, BCL2L1, AFF1, DDX5, MEIS1, MYCN, IGF1R, MAX, CDKN1A, FLI1, SP1, CCND2, GOLPH3, ETV6, RUNX1, HPGD, MLLT3 |
| TGF-beta signaling pathway | 23 | 2.58E−07 | BMP2, TNF, LTBP1, E2F5, SMAD7, GDF6, SMAD6, SMAD5, SMAD3, ACVR1C, ACVR2A, ACVR1B, EP300, SP1, ID1, PPP2CA, MAPK3, TGIF1, ID4, BMPR1B, PITX2, BMPR1A, TFDP1 |
| cGMP-PKG signaling pathway | 23 | 0.011286 | ADCY1, GNAI3, MAP2K1, ROCK2, RAF1, PDE3B, ATP1A2, PRKG1, PPP1CB, KCNMB2, MEF2D, SLC25A31, GNAQ, MAPK3, ADRA1B, CREB3L1, GUCY1B3, PPP3CA, PLCB1, INSR, CACNA1D, AKT3, NFATC1 |
| Adrenergic signaling in cardiomyocytes | 22 | 0.005094 | ADCY1, GNAI3, PPP2R5A, CAMK2G, CACNB2, ATP1A2, CACNB4, PPP1CB, TPM1, GNAQ, MAPK12, PPP2CA, MAPK3, KCNE1, ADRA1B, CREB3L1, GNAS, PLCB1, CACNA1D, CAMK2A, AKT3, PPP2R2D |
| Protein processing in endoplasmic reticulum | 22 | 0.017745 | SEC23A, RAD23B, SEC24A, DERL1, SYVN1, UBE4B, RNF185, DNAJB12, STUB1, SSR1, UBE2E3, BAK1, HSPA4L, ERN1, SIL1, MAPK9, AMFR, SEC24C, SEC24D, SAR1A, SEL1L, DNAJA2 |
| T cell receptor signaling pathway | 21 | 1.03E−04 | VAV3, TNF, MAP2K1, CBL, CTLA4, RAF1, IL10, NCK2, NRAS, FOS, PAK7, CBLB, MAPK12, JUN, PAK4, MAPK3, MAP3K8, PPP3CA, AKT3, IL2, NFATC1 |
| Insulin signaling pathway | 21 | 0.004921 | MAP2K1, CBL, PRKAB2, PHKA1, PRKAB1, ACACA, FOXO1, PDE3B, RAF1, PPP1CB, NRAS, PPP1R3D, CBLB, CRKL, PPP1R3F, MAPK3, FASN, MAPK9, PTPN1, INSR, AKT3 |
| GnRH signaling pathway | 20 | 2.91E−05 | ADCY1, MAP2K1, CAMK2G, MAP2K4, RAF1, PRKCD, NRAS, GNAQ, MAPK12, MAP3K2, JUN, MAP3K1, MAPK3, MAPK9, HBEGF, GNAS, PLCB1, CACNA1D, CAMK2A, MAP2K6 |
| Circadian entrainment | 20 | 1.37E−04 | ADCY1, GNAI3, CAMK2G, GRIA4, PRKG1, KCNJ5, FOS, GNAQ, GRIA2, GNB2, GNG10, MAPK3, PER2, PER1, GNAS, GUCY1B3, PER3, PLCB1, CACNA1D, CAMK2A |
| Melanogenesis | 20 | 1.57E−04 | WNT5A, ADCY1, GNAI3, MAP2K1, CAMK2G, LEF1, RAF1, FZD5, KITL, FZD4, TCF7L2, FZD7, NRAS, EP300, GNAQ, MAPK3, CREB3L1, GNAS, PLCB1, CAMK2A |
| Sphingolipid signaling pathway | 20 | 0.002751 | GNAI3, TNF, SPTLC1, MAP2K1, PPP2R5A, ROCK2, RAF1, SGMS1, PTEN, NRAS, S1PR3, GNAQ, MAPK12, PPP2CA, RAC1, MAPK3, MAPK9, PLCB1, AKT3, PPP2R2D |
| Hepatitis B | 20 | 0.015866 | E2F2, TNF, MAP2K1, MAP2K4, RAF1, PTEN, DDX58, NRAS, FOS, CCNE1, CDKN1A, EP300, JUN, MAP3K1, MAPK3, YWHAQ, CREB3L1, MAPK9, AKT3, NFATC1 |
| ErbB signaling pathway | 19 | 8.50E−05 | MAP2K1, CAMK2G, CBL, MAP2K4, RAF1, NCK2, NRAS, PAK7, CBLB, CDKN1A, CRKL, EREG, JUN, PAK4, MAPK3, HBEGF, MAPK9, CAMK2A, AKT3 |
| Chagas disease (American trypanosomiasis) | 19 | 7.62E−04 | ADCY1, TNF, GNAI3, MAP2K4, SMAD3, IL10, FOS, GNAQ, MAPK12, JUN, PPP2CA, MAPK3, IL12A, MAPK9, GNAS, PLCB1, AKT3, PPP2R2D, IL2 |
| Retrograde endocannabinoid signaling | 19 | 7.62E−04 | GABRG1, ADCY1, GABRA2, GNAI3, GABRA1, GRIA4, KCNJ5, SLC17A6, NAPEPLD, GNAQ, GRIA2, GNB2, MAPK12, CNR1, GNG10, MAPK3, MAPK9, PLCB1, CACNA1D |
| Cholinergic synapse | 19 | 0.002276 | ADCY1, GNAI3, MAP2K1, CAMK2G, KCNJ12, KCNJ14, NRAS, FOS, GNAQ, GNB2, GNG10, MAPK3, CHRNA4, CREB3L1, SLC5A7, PLCB1, CACNA1D, CAMK2A, AKT3 |
| Neurotrophin signaling pathway | 19 | 0.005293 | MAP2K1, NTF3, CAMK2G, RAF1, PRKCD, NRAS, CRKL, MAPK12, PRDM4, RPS6KA2, JUN, MAP3K1, RAC1, MAPK3, MAPK9, RAP1B, FRS2, CAMK2A, AKT3 |
| Lysosome | 19 | 0.005293 | AGA, CTSZ, AP4E1, AP1B1, CLTC, GNS, NPC1, AP1S2, LAPTM5, LAMP3, GNPTAB, AP3M1, AP3B2, GALC, GAA, AP3D1, GGA2, CLN5, AP3B1 |
| AMPK signaling pathway | 19 | 0.008048 | SCD1, CRTC2, PPP2R5A, PPARG, PRKAB2, PRKAB1, ACACA, FOXO1, CFTR, SIRT1, ADIPOQ, IGF1R, PPP2CA, FASN, CREB3L1, RAB10, INSR, AKT3, PPP2R2D |
| Vascular smooth muscle contraction | 19 | 0.008048 | ADCY1, MAP2K1, ROCK2, CALD1, PRKCH, RAF1, PRKG1, PRKCD, PPP1CB, KCNMB2, GNAQ, MAPK3, ADRA1B, PLA2G6, GNAS, GUCY1B3, CALCRL, PLCB1, CACNA1D |
| Adherens junction | 18 | 2.24E−05 | ACTN4, LEF1, ACTN1, SMAD3, SNAI2, TCF7L2, SNAI1, IQGAP1, VCL, IGF1R, TJP1, EP300, RAC1, MAPK3, WASL, PTPN1, YES1, INSR |
| Oocyte meiosis | 18 | 0.004111 | ADCY1, MAP2K1, PPP2R5A, CPEB3, CAMK2G, BTRC, PPP1CB, IGF1R, CCNE1, MAD2L1, SLK, RPS6KA2, PPP2CA, MAPK3, YWHAQ, PPP3CA, CAMK2A, FBXW11 |
| Amoebiasis | 18 | 0.007719 | COL4A3, IL1R1, ADCY1, TNF, ACTN4, ACTN1, ITGB2, COL5A2, IL10, VCL, GNAQ, LAMA5, IL12A, GNAS, SERPINB13, PLCB1, COL24A1, COL11A1 |
| Platelet activation | 18 | 0.022312 | ADCY1, GNAI3, ROCK2, PTGS1, PRKG1, PPP1CB, COL5A2, GNAQ, MAPK12, FGA, MAPK3, GNAS, GUCY1B3, RAP1B, PLCB1, COL24A1, COL11A1, AKT3 |
| Serotonergic synapse | 18 | 0.023857 | GNAI3, MAP2K1, PTGS1, MAOB, SLC6A4, HTR4, RAF1, KCNJ5, NRAS, APP, GNAQ, GNB2, GNG10, MAPK3, SLC18A2, GNAS, PLCB1, CACNA1D |
| Tight junction | 18 | 0.037031 | GNAI3, ACTN4, MPDZ, MRAS, PRKCH, ACTN1, AMOTL1, PRKCD, PTEN, CLDN15, NRAS, TJP1, PPP2CA, ASH1L, RAB13, YES1, AKT3, PPP2R2D |
| Estrogen signaling pathway | 17 | 0.003032 | ADCY1, GNAI3, MAP2K1, RAF1, PRKCD, KCNJ5, NRAS, FOS, GNAQ, SP1, JUN, MAPK3, CREB3L1, HBEGF, GNAS, PLCB1, AKT3 |
| Glucagon signaling pathway | 17 | 0.003732 | CRTC2, CAMK2G, PHKA1, PRKAB2, PRKAB1, ACACA, PDE3B, FOXO1, SIRT1, EP300, GNAQ, CREB3L1, GNAS, PPP3CA, PLCB1, CAMK2A, AKT3 |
| Choline metabolism in cancer | 17 | 0.004129 | MAP2K1, CHKB, RAF1, NRAS, FOS, HIF1A, SP1, DGKE, JUN, DGKG, MAPK3, RAC1, MAPK9, SLC5A7, WASL, PDGFD, AKT3 |
| Insulin resistance | 17 | 0.009491 | CRTC2, TNF, PRKAB2, PRKAB1, FOXO1, PRKCD, PTEN, PPP1CB, PPP1R3D, RPS6KA2, MLX, CREB3L1, MAPK9, OGT, PTPN1, INSR, AKT3 |
| Glutamatergic synapse | 17 | 0.014278 | SLC38A3, ADCY1, GNAI3, SLC38A2, GRIK5, GRIA4, HOMER1, SLC17A6, GNAQ, GRIA2, GNB2, GNG10, MAPK3, GNAS, PPP3CA, PLCB1, CACNA1D |
| Ubiquitin mediated proteolysis | 17 | 0.077448 | SYVN1, UBE3A, BTRC, UBE4B, CBL, BIRC6, UBE2H, HERC2, STUB1, CUL3, UBE2E3, CBLB, MAP3K1, WWP1, UBE2M, TRIM32, FBXW11 |
| Prostate cancer | 16 | 0.002635 | E2F2, MAP2K1, FOXO1, RAF1, LEF1, PTEN, TCF7L2, NRAS, IGF1R, CCNE1, CDKN1A, EP300, MAPK3, CREB3L1, PDGFD, AKT3 |
| Thyroid hormone signaling pathway | 16 | 0.02557 | KAT2B, MAP2K1, RAF1, FOXO1, MED13, ATP1A2, NRAS, NCOA1, NOTCH1, HIF1A, EP300, NCOA3, MAPK3, DIO1, PLCB1, AKT3 |
| Inflammatory mediator regulation of TRP channels | 16 | 0.058489 | IL1R1, ADCY1, PTGER4, CAMK2G, TRPA1, PRKCH, PRKCD, PPP1CB, GNAQ, MAPK12, PLA2G6, MAPK9, GNAS, PLCB1, CAMK2A, MAP2K6 |
| Osteoclast differentiation | 16 | 0.058489 | IL1R1, TNF, MAP2K1, CSF1, PPARG, FOS, TNFSF11, MAPK12, JUN, MAPK3, RAC1, MAPK9, PPP3CA, MAP2K6, AKT3, NFATC1 |
| Long-term potentiation | 15 | 3.92E−04 | ADCY1, MAP2K1, CAMK2G, RAF1, PPP1CB, NRAS, EP300, GNAQ, GRIA2, RPS6KA2, MAPK3, RAP1B, PPP3CA, PLCB1, CAMK2A |
| Salmonella infection | 15 | 0.0022 | DYNC1I1, DYNC1LI2, ROCK2, ARPC1A, FOS, TJP1, MAPK12, ARPC2, JUN, MAPK3, RAC1, MAPK9, WASL, DYNC1H1, DYNC1I2 |
| Gap junction | 15 | 0.005529 | ADCY1, GNAI3, MAP2K1, RAF1, LPAR1, PRKG1, NRAS, TJP1, GNAQ, MAP3K2, MAPK3, GNAS, GUCY1B3, PDGFD, PLCB1 |
| Toll-like receptor signaling pathway | 15 | 0.02171 | TNF, MAP2K1, MAP2K4, CXCL9, FOS, MAPK12, JUN, RAC1, MAPK3, MAP3K8, IL12A, MAPK9, MAP2K6, AKT3, TRAF3 |
| TNF signaling pathway | 15 | 0.038777 | TNF, DNM1L, MAP2K1, CSF1, MAP2K4, FOS, MAPK12, JUN, MAPK3, MAP3K8, CREB3L1, MAPK9, AKT3, MAP2K6, TRAF3 |
| Cell cycle | 15 | 0.093007 | E2F2, E2F5, CDC14B, SMAD3, CDK7, CCNE1, CDKN1A, MAD2L1, EP300, RAD21, CCND2, YWHAQ, GADD45A, STAG2, TFDP1 |
| Amphetamine addiction | 14 | 0.001509 | CAMK2G, MAOB, GRIA4, PPP1CB, SIRT1, FOS, GRIA2, JUN, SLC18A2, CREB3L1, GNAS, PPP3CA, CACNA1D, CAMK2A |
| Renal cell carcinoma | 14 | 0.001509 | MAP2K1, RAF1, HGF, PAK7, NRAS, CRKL, EP300, HIF1A, PAK4, JUN, RAC1, MAPK3, RAP1B, AKT3 |
| Fc gamma R-mediated phagocytosis | 14 | 0.011216 | VAV3, MAP2K1, RAF1, ARF6, PRKCD, AMPH, ARPC1A, CRKL, ARPC2, MAPK3, RAC1, MARCKS, WASL, AKT3 |
| GABAergic synapse | 14 | 0.014861 | GABRG1, SLC38A3, ADCY1, GABRA2, GNAI3, GABRA1, SLC38A2, SLC6A1, GNB2, TRAK2, GNG10, ABAT, CACNA1D, NSF |
| Long-term depression | 13 | 0.002005 | GNAI3, MAP2K1, RAF1, PRKG1, IGF1R, NRAS, GRIA2, GNAQ, PPP2CA, MAPK3, GNAS, GUCY1B3, PLCB1 |
| Progesterone-mediated oocyte maturation | 13 | 0.033215 | ADCY1, GNAI3, MAP2K1, CPEB3, PDE3B, RAF1, IGF1R, MAD2L1, MAPK12, RPS6KA2, MAPK3, MAPK9, AKT3 |
| Colorectal cancer | 12 | 0.008821 | FOS, MAP2K1, JUN, MAPK3, RAC1, MAPK9, RAF1, SMAD3, LEF1, TCF7L2, AKT3, AXIN1 |
| Fc epsilon RI signaling pathway | 12 | 0.013779 | NRAS, TNF, VAV3, MAPK12, MAP2K1, MAPK3, MAP2K4, RAC1, MAPK9, RAF1, AKT3, MAP2K6 |
| Melanoma | 12 | 0.018702 | NRAS, IGF1R, E2F2, CDKN1A, FGF7, MAP2K1, MAPK3, RAF1, PDGFD, HGF, PTEN, AKT3 |
| Chronic myeloid leukemia | 12 | 0.020602 | NRAS, E2F2, CDKN1A, CBLB, CRKL, MAP2K1, MAPK3, CBL, RAF1, BCL2L1, RUNX1, AKT3 |
| Prolactin signaling pathway | 12 | 0.022641 | NRAS, FOS, TNFSF11, MAPK12, MAP2K1, CCND2, MAPK3, MAPK9, RAF1, SOCS7, AKT3, CISH |
| Pertussis | 12 | 0.024823 | FOS, GNAI3, TNF, NOD1, MAPK12, JUN, MAPK3, IL12A, MAPK9, ITGB2, SERPING1, IL10 |
| Insulin secretion | 12 | 0.06389 | ADCY1, GNAQ, CAMK2G, CREB3L1, GNAS, ATP1A2, VAMP2, PLCB1, CAMK2A, CACNA1D, ADCYAP1, KCNMB2 |
| Circadian rhythm | 11 | 6.68E−05 | CRY2, NR1D1, BTRC, PRKAB2, PRKAB1, PER2, PER1, PER3, FBXW11, CLOCK, FBXL3 |
| Glioma | 11 | 0.025453 | NRAS, IGF1R, E2F2, CDKN1A, MAP2K1, CAMK2G, MAPK3, RAF1, PTEN, CAMK2A, AKT3 |
| B cell receptor signaling pathway | 11 | 0.040119 | NRAS, FOS, VAV3, MAP2K1, JUN, MAPK3, RAC1, RAF1, PPP3CA, AKT3, NFATC1 |
| Salivary secretion | 11 | 0.069082 | CD38, ADCY1, GNAQ, SLC12A2, ADRA1B, GNAS, GUCY1B3, ATP1A2, VAMP2, PLCB1, PRKG1 |
| Bacterial invasion of epithelial cells | 11 | 0.074081 | ARPC1A, CAV2, CBLB, CAV1, CRKL, ARPC2, CBL, RAC1, WASL, CLTC, VCL |
| Synaptic vesicle cycle | 10 | 0.045841 | ATP6V1C1, SYT1, CPLX2, SLC17A6, SLC18A2, ATP6V1B2, VAMP2, CLTC, UNC13C, NSF |
| Pancreatic cancer | 10 | 0.059074 | E2F2, MAP2K1, MAPK3, RAC1, MAPK9, RAF1, RALA, SMAD3, BCL2L1, AKT3 |
| Arrhythmogenic right ventricular cardiomyopathy | 10 | 0.092277 | ACTN4, DMD, ITGA1, CACNB2, ACTN1, LEF1, CACNB4, ITGA4, CACNA1D, TCF7L2 |
| Renin secretion | 10 | 0.092277 | GNAI3, GNAQ, PTGER4, PDE3B, GNAS, GUCY1B3, PPP3CA, PLCB1, CACNA1D, ADCYAP1 |
| Vasopressin-regulated water reabsorption | 9 | 0.015204 | DYNC1I1, DYNC1LI2, CREB3L1, GNAS, VAMP2, DYNC1H1, DYNC1I2, NSF, AQP2 |
| Endometrial cancer | 9 | 0.04321 | NRAS, MAP2K1, MAPK3, RAF1, LEF1, PTEN, TCF7L2, AKT3, AXIN1 |
| Acute myeloid leukemia | 9 | 0.062572 | NRAS, MAP2K1, MAPK3, RUNX1T1, RAF1, LEF1, RUNX1, TCF7L2, AKT3 |
| Malaria | 8 | 0.071947 | LRP1, TNF, COMP, IL12A, ITGB2, HGF, SDC2, IL10 |
| Amyotrophic lateral sclerosis | 8 | 0.093164 | DERL1, TNF, GRIA2, MAPK12, RAC1, BCL2L1, PPP3CA, MAP2K6 |
| Dorso-ventral axis formation | 7 | 0.010038 | NOTCH1, MAP2K1, CPEB3, ETS1, ETS2, MAPK3, ETV6 |
| Nicotine addiction | 7 | 0.082655 | GABRG1, GABRA2, SLC17A6, GABRA1, GRIA2, CHRNA4, GRIA4 |
| Bladder cancer | 7 | 0.090875 | NRAS, E2F2, CDKN1A, MAP2K1, MAPK3, RAF1, HBEGF |
| Thyroid cancer | 6 | 0.067242 | NRAS, MAP2K1, PPARG, MAPK3, LEF1, TCF7L2 |
| Sulfur metabolism | 4 | 0.046731 | SQRDL, PAPSS1, BPNT1, PAPSS2 |