Figure 1. Up-regulated miRs affecting growth of pancreatic ductal adenocarcinoma targeting tumor suppressors in preclinical in vivo models. miRs- 10b, -194 and -451 affect tumor growth via the outlined targets. CAB39: Calcium biding protein 39; DACH1: dachshund homolog 1; EGFR-P: phosphorylated epidermal growth factor receptor; ERK: extracellular signal regulated kinase 1; LKB1: liver kinase B1; STK11: serine-threonine kinase 11.
