Figure 3. Down-regulated miRs affecting growth of pancreatic ductal adenocarcinoma-related xenografts. miRs -96, -10b, -141, -148 and -663 are down-regulated and interfere with the targets as outlined. AMPKα1: AMP-activated protein kinase; eEFA2: eukaryotic initiation factor A2; ERK: extracellular signal regulated kinase; KRAS: Kirsten rat sarcoma; mTOR: mammalian target of rapamycin; MAP4K4: mitogen-activated protein kinase kinase kinase kinase 4; NFĸB: nuclear factor ĸB; PI3K: phosphoinosite 3-kinase; STAT 3: signal transducer and activator of transcription 3.
