Figure 4. miRs affecting metastasis of pancreatic ductal adenocarcinoma xenografts. miR-367 is up-regulated, whereas miRs -29c, -143, -323-3p, -367, -454-5p, and miR-489, are down-regulated in pancreatic tumors in comparison to corresponding normal pancreatic tissues models. The corresponding targets are shown. ADAM 9: A disintegrin and metalloproteinase 9; ARHGEF1,2: rho guanine nucleotide exchange factor 1,2; KRAS: kirsten rat sarcoma; LRP6: low-density lipoprotein-related protein C; MMP2,7: matrix metalloproteinase 2,7.