Liguori 1998.
Methods | Randomization: yes Participant blinding: yes Provider blinding: no Assessor blinding: yes Dropouts: 3 outcomes not reported |
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Participants | Country: USA ASA: I, II, and III Gender: men and women Mean age: lido: 38 (SD 12); mepi: 42 (SD 10) years Procedures: arthroscopy Ambulatory surgery: yes Surgical positioning: supine Number of participants: 60 |
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Interventions | Drug 1: 2% lido, baricity unclear, fixed dose (3 mL) Drug 2: 1.5% mepi, baricity unclear, fixed dose (3 mL) Needle: 27 G, pencil‐point |
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Outcomes | TNS at 1–2 days | |
Notes | Follow‐up duration: 2–5 days Follow‐up method: telephone contact TNS therapy: NSAIDs TNS resolution: duration 1–5 days |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Quote: "the patients were assigned using a random‐number table to receive either 2% 3 ml (60 mg) lidocaine… or 1.5% 3 ml (45 mg) mepivacaine…" |
Allocation concealment (selection bias) | Unclear risk | No mention of allocation concealment. |
Participant blinding (performance bias and detection bias) | Low risk | Quote: "…we decided to re‐evaluate mepivacaine… in a randomized, double‐blind comparison with isobaric 2% lidocaine…" |
Provider blinding (performance bias) | Low risk | Quote: "…we decided to re‐evaluate mepivacaine… in a randomized, double‐blind comparison with isobaric 2% lidocaine…" |
Assessor blinding (detection bias) | Low risk | Quote: "patients were contacted… by one of the investigators who was blinded to group assignment." |
Incomplete outcome data (attrition bias) All outcomes | High risk | 3 participants in lido group lost to follow‐up. Dropout outcomes not reported. |
Selective reporting (reporting bias) | Unclear risk | Study protocol not available. |