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. 2019 Dec 1;2019(12):CD003006. doi: 10.1002/14651858.CD003006.pub4

Liguori 1998.

Methods Randomization: yes
Participant blinding: yes
Provider blinding: no
Assessor blinding: yes
Dropouts: 3 outcomes not reported
Participants Country: USA
ASA: I, II, and III
Gender: men and women
Mean age: lido: 38 (SD 12); mepi: 42 (SD 10) years
Procedures: arthroscopy
Ambulatory surgery: yes
Surgical positioning: supine
Number of participants: 60
Interventions Drug 1: 2% lido, baricity unclear, fixed dose (3 mL)
Drug 2: 1.5% mepi, baricity unclear, fixed dose (3 mL)
Needle: 27 G, pencil‐point
Outcomes TNS at 1–2 days
Notes Follow‐up duration: 2–5 days
Follow‐up method: telephone contact
TNS therapy: NSAIDs
TNS resolution: duration 1–5 days
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Quote: "the patients were assigned using a random‐number table to receive either 2% 3 ml (60 mg) lidocaine… or 1.5% 3 ml (45 mg) mepivacaine…"
Allocation concealment (selection bias) Unclear risk No mention of allocation concealment.
Participant blinding (performance bias and detection bias) Low risk Quote: "…we decided to re‐evaluate mepivacaine… in a randomized, double‐blind comparison with isobaric 2% lidocaine…"
Provider blinding (performance bias) Low risk Quote: "…we decided to re‐evaluate mepivacaine… in a randomized, double‐blind comparison with isobaric 2% lidocaine…"
Assessor blinding (detection bias) Low risk Quote: "patients were contacted… by one of the investigators who was blinded to group assignment."
Incomplete outcome data (attrition bias) 
 All outcomes High risk 3 participants in lido group lost to follow‐up. Dropout outcomes not reported.
Selective reporting (reporting bias) Unclear risk Study protocol not available.