Table 2.
Univariable analysis for the potential factors influencing clinical outcomes of IVF/ICSI
| Exposure | Statistics | cLBR | Miscarriage rate | Preterm birth | |||
|---|---|---|---|---|---|---|---|
| OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | P | ||
| Female age (years) | Mean ± SD | ||||||
| 30.0 ± 3.7 | 0.975 (0.943, 1.008) | 0.139 | 1.056 (0.996, 1.120) | 0.069 | 0.970 (0.926, 1.016) | 0.064 | |
| BMI (kg/m2) | 22.1 ± 2.8 | 0.953 (0.912, 0.995) 0.953 (0.912, 0.995) 0.953 (0.912, 0.995) | 0.030 | 1.009 (0.933, 1.092) | 0.821 | 1.036 (0.977, 1.098) | 0.241 |
| Infertility duration (years) | 3.8 ± 2.7 | 1.016 (0.970, 1.065) | 0.507 | 1.020 (0.941, 1.105) | 0.635 | 0.940 (0.877, 1.008) | 0.084 |
| Basal AFC | 16.8 ± 6.7 | 0.983 (0.966, 1.001) | 0.068 | 1.025 (0.994, 1.057) | 0.117 | 1.023 (0.998, 1.047) | 0.067 |
| Basal FSH (IU/L) | 7.3 ± 3.3 | 0.990 (0.950, 1.032) | 0.639 | 0.983 (0.902, 1.071) | 0.692 | 1.010 (0.956, 1.067) | 0.726 |
| Basal E2 (pg/ml) | 53.8 ± 35.5 | 1.001 (0.997, 1.005) | 0.573 | 0.993 (0.984, 1.002) | 0.14 | 0.998 (0.993, 1.004) | 0.54 |
| Peak E2 on hCG trigger day (100 pg/ml) | 39.1 ± 13.2 | 1.001 (0.992, 1.012) | 0.822 | 1.003 (0.986, 1.021) | 0.708 | 1.012 (0.999, 1.025) | 0.076 |
| Antral follicular count on hCG day (≥ 14 mm) | 11.2 ± 3.6 | 1.017 (0.983, 1.053) | 0.341 | 1.035 (0.973, 1.101) | 0.278 | 1.015 (0.968, 1.064) | 0.537 |
| Total dose of Gn administered (IU) | 1953.4 ± 898.9 | 1.000 (0.999, 1.000) | 0.878 | 1.000 (0.999, 1.000) | 0.857 | 0.999 (0.999, 1.000) | 0.033 |
| Number of oocytes retrieved | 3.8 ± 2.7 | 1.004 (0.981, 1.027) | 0.736 | 1.010 (0.970, 1.051) | 0.646 | 1.020 (0.989, 1.051) | 0.215 |
| Infertility etiology (data missing, n = 2) | n [%] | ||||||
| Tubal factor (n [%]) | 653 (55.3) | 1 | 1 | 1 | |||
| Male factor (n [%]) | 126 (10.7) | 1.582 (1.023, 2.426) | 0.039 | 0.709 (0.314, 1.603) | 0.409 | 0.868 (0.484, 1.556) | 0.634 |
| Mixed factor (n [%]) | 291 (24.7) | 1.142 (0.851, 1.533) | 0.376 | 1.183 (0.721, 1.942) | 0.506 | 0.964 (0.641, 1.451) | 0.862 |
| Unexplained (n [%]) | 66 (5.6) | 1.003 (0.590, 1.706) | 0.991 | 0.186 (0.025, 1.365) | 0.098 | 1.729 (0.919, 3.250) | 0.089 |
| Stimulation protocol (data missing, n = 4) | |||||||
| GnRH-agonist protocol (n [%]) | 1071 (93.9) | 1 | 1 | 1 | |||
| GnRH-antagonist protocol (n [%]) | 69 (6.1) | 1.225 (0.717, 2.092) | 0.458 | 0.981 (0.384, 2.508) | 0.968 | 0.372 (0.134, 1.036) | 0.059 |
| Method of fertilization | |||||||
| IVF (n [%]) | 831 (72.8) | 1 | 1 | 1 | |||
| ICSI (n [%]) | 241 (21.1) | 1.532 (1.109, 2.113) | 0.009 | 0.782 (0.438, 1.398) | 0.407 | 0.803 (0.520, 1.238) | 0.32 |
| IVF + ICSI (n [%]) | 69 (6.1) | 1.568 (0.899, 2.733) | 0.113 | 0.725 (0.256, 2.054) | 0.545 | 0.559 (0.237, 1.319) | 0.184 |
| Development stage and embryo quality of transferred embryos (data missing, n = 16) | |||||||
| 1 or 2 Grade 1 D3 embryos (n [%]) | 231 (20.5) | 1 | 1 | 1 | |||
| 1 or 2 Grade 2 D3 embryos (n [%]) | 487 (43.3) | 0.425 (0.295, 0.611) | < 0.0001 | 1.501 (0.767, 2.935) | 0.236 | 1.228 (0.774, 1.949) | 0.383 |
| 1 Grade 2 and 1 Grade 1 D3 embryos (n [%]) | 274 (24.4) | 0.524 (0.350, 0.784) | 0.002 | 1.437 (0.687, 3.006) | 0.336 | 1.297 (0.781, 2.154) | 0.316 |
| Single blastocyst (n [%]) | 124 (11.0) | 0.551(0.331, 0.892) | 0.015 | 2.322 (1.043, 5.192) | 0.040 | 0.480 (0.213, 1.086) | 0.078 |
| Fresh or frozen embryo transfer | |||||||
| Fresh embryo transfer (n [%]) | 377 (33.0) | 1 | 1 | 1 | |||
| FET (n [%]) | 764 (67.0) | 0.899 (0.691, 1.171) | 0.431 | 1.632 (0.972, 2.740) | 0.064 | 0.985 (0.688, 1.410) | 0.934 |
Factors with less than 10 cases were not included in the univariable analysis: endometriosis (n = 5) in infertility factors, other stimulation strategy (n = 1) in stimulation strategies and blastocyst + embryo transfer (n = 9) in development of transferred embryos