Table 2.
The genotype distribution of miR-146a C > G, miR-149 T > C, miR-196a2 T > C, and miR-499 A > G polymorphisms in the case and control subjects
| Genotypes | Cases (n = 120) (%) | Controls (n = 90) (%) | p valuea | OR (95% CI) |
|---|---|---|---|---|
| miR-146a C > G | 0.031 | – | ||
| CC | 67.50 | 50.00 | 0.015 | 0.481 (0.274–0.845) |
| CG | 29.20 | 46.70 | 0.014 | 2.125 (1.200–3.763) |
| GG | 3.30 | 3.30 | 1.000 | 1.000 (0.218–4.584) |
| Carrier (CG + GG)b | 32.50 | 50.00 | 0.015 | 2.077 (1.183–3.646) |
|
Frequency of G allele HWE p valuec |
17.91 0.008 |
26.65 2.017 |
0.042 | 0.600 (0.376–0.957) |
| miR-149 T > C | 0.034 | – | ||
| TT | 58.30 | 75.60 | 0.012 | 2.208 (1.209–4.032) |
| TC | 40.00 | 23.30 | 0.012 | 0.457 (0.248–0.840) |
| CC | 1.70 | 1.10 | 1.000 | 0.663 (0.059–7.427) |
| Carrier (TC + CC)b | 41.70 | 24.40 | 0.012 | 0.453 (0.248–0.827) |
|
Frequency of C allele HWE p valuec |
21.66 3.819 |
12.77 0.197 |
0.020 | 1.888 (1.106–3.222) |
| miR-196a2 T > C | 0.627 | – | ||
| TT | 74.20 | 78.90 | 0.513 | 1.302 (0.679–2.495) |
| TC | 23.30 | 20.00 | 0.615 | 0.821 (0.421–1.601) |
| CC | 2.50 | 1.10 | 0.637 | 0.438 (0.045–4.284) |
| Carrier (TC + CC)b | 25.80 | 21.10 | 0.513 | 0.768 (0.401–1.473) |
|
Frequency of C allele HWE p valuec |
14.15 0.198 |
11.11 0.014 |
0.380 | 1.320 (0.732–2.381) |
| miR-499A > G | 0.083 | – | ||
| AA | 12.50 | 17.80 | 0.328 | 1.514 (0.705–3.251) |
| AG | 47.50 | 56.70 | 0.211 | 1.145 (0.834–2.504) |
| GG | 40.00 | 25.50 | 0.039 | 0.515 (0.283–0.936) |
| Carrier (AG + GG)b | 87.50 | 82.20 | 0.328 | 0.661 (0.308–1.419) |
|
Frequency of G allele HWE p valuec |
64.16 0.092 |
53.90 1.769 |
0.045 | 1.505 (1.015–2.231) |
HWE Hardy-Weinberg Equilibrium, OR odds ratio, CI confidence interval
aEvaluated by Pearson’s chi-squared test
bCarriers; individuals who had either heterozygous and homozygous specified polymorphism
cCalculated by Hardy-Weinberg Equilibrium