Table 3.
Combination analysis of miR-146a C > G, miR-149 T > C, miR-196a2 T > C, and miR-499 A > G polymorphisms in the case and control subjects
| Genotypes | Cases (n = 120) (%) | Controls (n = 90) (%) | p valuea | OR (95% CI) |
|---|---|---|---|---|
| miR-146a/miR-149 | ||||
| CC/TT | 45 (37.50) | 27 (30.00) | 0.304 | 1.400 (0.782–2.508) |
| CC/TC | 34 (28.33) | 17 (18.88) | 0.143 | 1.698 (0.877–3.286) |
| CC/CC | 2 (1.66) | 1 (1.11) | 1.000 | 1.508 (0.135–16.89) |
| CG/TT | 23 (19.16) | 38 (42.22) | 0.0001 | 0.324 (0.175–0.602) |
| CG/TC | 12 (10.00) | 4 (4.44) | 0.189 | 2.389 (0.744–7.670) |
| CG/CC | 0 (0.00) | 0 (0.00) | ND | ND |
| GG/TT | 2 (1.66) | 3 (3.33) | 0.653 | 0.492 (0.080–3.005) |
| GG/TC | 2 (1.66) | 0 (0.00) | 0.508 | 0.983 (0.961–1.007) |
| GG/CC | 0 (0.00) | 0 (0.00) | ND | ND |
| miR-146a/miR-196a2 | ||||
| CC/TT | 60 (50.00) | 33 (36.66) | 0.068 | 1.727 (0.988–3.019) |
| CC/TC | 19 (15.83) | 11 (12.22) | 0.552 | 1.351 (0.608–3.003) |
| CC/CC | 2 (1.66) | 1 (1.11) | 1.000 | 1.508 (0.135–16.89) |
| CG/TT | 26 (21.66) | 35 (38.88) | 0.009 | 0.435 (0.237–0.797) |
| CG/TC | 8 (6.66) | 10 (11.11) | 0.321 | 0.571 (0.216–1.512) |
| CG/CC | 1 (0.83) | 0 (0.00) | 1.000 | 0.992 (0.976–1.008) |
| GG/TT | 3 (2.50) | 3 (3.33) | 1.000 | 0.774 (0.147–3.773) |
| GG/TC | 1 (0.83) | 0 (0.00) | 1.000 | 0.992 (0.976–1.008) |
| GG/CC | 0 (0.00) | 0 (0.00) | ND | ND |
| miR-146a/miR-499 | ||||
| CC/AA | 11 (9.16) | 8 (8.88) | 1.000 | 1.034 (0.398–2.689) |
| CC/AG | 42 (35.00) | 27 (30.00) | 0.462 | 1.256 (0.699–2.259) |
| CC/GG | 28 (23.33) | 10 (11.11) | 0.029 | 2.435 (1.114–5.321) |
| CG/AA | 4 (3.33) | 7 (7.77) | 0.212 | 0.409 (0.116–1.44) |
| CG/AG | 13 (10.83) | 25 (27.77) | 0.002 | 0.316 (0.151–0.661) |
| CG/GG | 18 (15.00) | 13 (14.44) | 1.000 | 1.045 (0.483–2.263) |
| GG/AA | 1 (0.83) | 1 (1.11) | 1.000 | 0.748 (0.046–12.12) |
| GG/AG | 1 (0.83) | 2 (2.22) | 0.586 | 0.370 (0.033–4.412) |
| GG/GG | 2 (1.66) | 0 (0.00) | 0.508 | 0.983 (0.961–1.007) |
| miR-149/miR-196a2 | ||||
| TT/TT | 53 (44.16) | 52 (57.77) | 0.070 | 0.578 (0.333–1.004) |
| TT/TC | 16 (13.33) | 15 (16.66) | 0.558 | 0.769 (0.358–1.652) |
| TT/CC | 1 (0.83) | 1 (1.11) | 1.000 | 0.748 (0.046–12.12) |
| TC/TT | 34 (28.33) | 18 (20.00) | 0.197 | 1.581 (0.824–3.034) |
| TC/TC | 12 (10.00) | 3 (3.33) | 0.102 | 3.222 (0.881–11.77) |
| TC/CC | 2 (1.66) | 0 (0.00) | 0.508 | 0.983 (0.961–1.007) |
| CC/TT | 2 (1.66) | 1 (1.11) | 1.000 | 1.508 (0.135–16.89) |
| CC/TC | 0 (0.00) | 0 (0.00) | ND | ND |
| CC/CC | 0 (0.00) | 0 (0.00) | ND | ND |
| miR-149/miR-499 | ||||
| TT/AA | 8 (6.66) | 9 (10.00) | 0.447 | 0.643 (0.238–1.738) |
| TT/AG | 31 (25.83) | 41 (45.55) | 0.003 | 0.416 (0.223–0.745) |
| TT/GG | 31 (25.83) | 18 (20.00) | 0.410 | 1.393 (0.721–2.692) |
| TC/AA | 7 (5.83) | 7 (7.77) | 0.598 | 0.735 (0.248–2.174) |
| TC/AG | 25 (20.83) | 9 (10.00) | 0.038 | 2.368 (1.046–5.364) |
| TC/GG | 16 (13.33) | 5 (5.55) | 0.068 | 2.165 (0.920–7.431) |
| CC/AA | 1 (0.83) | 0 (0.00) | 1.000 | 0.992 (0.976–1.008) |
| CC/AG | 0 (0.00) | 1 (1.11) | 0.429 | 1.011 (0.989–1.034) |
| CC/GG | 1 (0.83) | 0 (0.00) | 1.000 | 0.992 (0.976–1.008) |
| miR-196a2/miR-499 | ||||
| TT/AA | 12 (10.00) | 13 (14.44) | 0.391 | 0.658 (0.285–1.520) |
| TT/AG | 40 (33.33) | 42 (46.66) | 0.063 | 0.571 (0.326–1.002) |
| TT/GG | 37 (30.83) | 16 (17.77) | 0.037 | 2.062 (1.060–4.009) |
| TC/AA | 3 (2.50) | 3 (3.33) | 1.000 | 0.774 (0.147–3.773) |
| TC/AG | 14 (11.66) | 8 (8.88) | 0.650 | 1.354 (0.542–3.381) |
| TC/GG | 11 (9.16) | 7 (7.77) | 0.807 | 1.197 (0.445–3.219) |
| CC/AA | 1 (0.83) | 0 (0.00) | 1.000 | 0.992 (0.976–1.008) |
| CC/AG | 2 (1.66) | 1 (1.11) | 1.000 | 1.508 (0.135–16.89) |
| CC/GG | 0 (0.00) | 0 (0.00) | ND | ND |
OR odds ratio, CI confidence interval, ND not determined
aEvaluated by Fisher’s chi-squared test