TABLE 2.
Characteristics of the study's participants organized by vitamin K abundance clusters1
| Mean ± SD | Cluster vs. cluster P2 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Characteristic | Cluster 1 (n = 11) | Cluster 2 (n = 29) | Cluster 3 (n = 11) | Cluster 4 (n = 15) | P 3 | 1 vs. 2 | 1 vs. 3 | 1 vs. 4 | 2 vs. 3 | 2 vs. 4 | 3 vs. 4 |
| MMSE score | 15 ± 9.7 | 23 ± 7.5 | 27 ± 4.6 | 26 ± 4 | 0.0013 | 0.0353 | <0.0013 | 0.0012 | 0.0322 | 0.123 | 0.272 |
| Age, y | 85 ± 7.4 | 80 ± 9.6 | 76 ± 8.3 | 75 ± 6.8 | 0.0193 | 0.121 | 0.0152 | 0.0102 | 0.100 | 0.118 | 0.400 |
| Barthel score | 8.3 ± 6.5 | 14.7 ± 7.1 | 17.4 ± 4.9 | 18.5 ± 3.6 | <0.0013 | 0.025 2 | <0.0012 | 0.0422 | <0.0012 | 0.0392 | 0.323 |
| No. of hypertension medications | 0.18 ± 0.4 | 0.53 ± 0.9 | 0.45 ± 0.9 | 0.27 ± 0.6 | 0.759 | 1.000 | 0.508 | 0.433 | 0.471 | 0.594 | 0.480 |
| No. of diabetes medications | 0 ± 0 | 0.21 ± 0.5 | 0.07 ± 0.3 | 0 ± 0 | <0.0013 | 0.105 | 0.396 | 0.500 | 0.0712 | 0.140 | 0.469 |
| No. of diagnoses | 5.9 ± 2.9 | 3.7 ± 2 | 2.2 ± 1.8 | 2.8 ± 2 | 0.0013 | 0.090 | 0.0012 | 0.0122 | 0.0142 | 0.112 | 0.188 |
| No. of drugs | 6.3 ± 3.2 | 4.7 ± 2.9 | 4.8 ± 3.6 | 4.8 ± 1.9 | 0.339 | 0.199 | 0.220 | 0.413 | 0.221 | 0.485 | 0.480 |
| Serum PK, nmol/L | 0.82 ± 08 | 0.86 ± 0.8 | 1.18 ± 1.5 | 0.73 ± 0.5 | 0.043 | 0.582 | 0.347 | 0.489 | 0.720 | 0.706 | 0.468 |
| TNF-α, IU | 7.89 ± 3.7 | 9.97 ± 12.5 | 4.79 ± 1.9 | 5.64 ± 2.8 | 0.0333 | 0.177 | 0.0182 | 0.083 | 0.091 | 0.240 | 0.191 |
| IL-6, IU | 13.13 ± 12.7 | 28.08 ± 51.1 | 5.96 ± 3.5 | 17.67 ± 42.8 | 0.0253 | 0.351 | 0.101 | 0.221 | 0.0132 | 0.087 | 0.252 |
| IL-8, IU | 25.56 ± 17.5 | 18.59 ± 8.4 | 20.38 ± 26.4 | 14.42 ± 7.8 | 0.198 | 0.2392 | 0.2003 | 0.1318 | 0.2237 | 0.1486 | 0.2878 |
| Diversity: Shannon index | 3.04 ± 0.4 | 3.53 ± 0.3 | 3.79 ± 0.5 | 3.55 ± 0.6 | 0.0013 | 0.0172 | <0.0012 | 0.0182 | 0.0512 | 0.499 | 0.058 |
| BMI, kg/m2 | 23.7 ± 5.8 | 27 ± 4.5 | 26.5 ± 5.8 | 29.8 ± 8.8 | 0.123 | 0.047 | 0.083 | 0.290 | 0.091 | 0.439 | 0.316 |
Values are means ± SD. Individual values can be found in Supplemental Table 7. MMSE, Mini-Mental State Examination; PK, phylloquinone.
P < 0.05, Dunn post hoc test for pairwise comparisons.
P < 0.05, Kruskal-Wallis test.