Table 4.
Common signaling pathways between uterine leiomyomas and the SATB2 or NRG1 lines
| # | Common pathways in the SATB2 line and uterine leiomyomas (63) | p value for the SATB2 line | Common pathways in the NRG1 line and uterine leiomyomas (33) | p value for the NRG1 line |
|---|---|---|---|---|
| 1 | Axonal guidance signaling | 2.09 × 10−7 | Human embryonic stem cell pluripotency | 1.15 × 10−5 |
| 2 | Hepatic fibrosis/hepatic stellate cell activation | 1.23 × 10−6 | Role of osteoblasts, osteoclasts and chondrocytes in rheumatoid arthritis | 1.66 × 10−5 |
| 3 | Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis | 8.91 × 10−6 | Hepatic fibrosis/hepatic stellate cell activation | 4.07 × 10−5 |
| 4 | Osteoarthritis pathway | 9.33 × 10−6 | G protein coupled receptor signaling | 1.38 × 10−4 |
| 5 | Leukocyte extravasation signaling | 3.55 × 10−5 | Regulation of the Epithelial-mesenchymal transition pathway | 1.70 × 10−4 |
| 6 | Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis | 3.80 × 10−5 | Adipogenesis pathway | 1.41 × 10−3 |
| 7 | Pancreatic adenocarcinoma signaling | 8.71 × 10−5 | Role of macrophages, fibroblasts and endothelial cells in rheumatoid arthritis | 1.55 × 10−3 |
| 8 | Human embryonic stem cell pluripotency | 1.38 × 10−4 | Wnt/β-catenin signaling | 2.82 × 10−3 |
| 9 | Granulocyte adhesion and diapedesis | 2.45 × 10−4 | Retinoic acid mediated apoptosis signaling | 4.27 × 10−3 |
| 10 | Molecular Mechanisms of Cancer | 4.90 × 10−4 | TGF-β signaling | 4.57 × 10−3 |
| 11 | Atherosclerosis signaling | 6.46 × 10−4 | Osteoarthritis pathway | 5.62 × 10−3 |
| 12 | Virus Entry via Endocytic Pathways | 7.59 × 10−4 | Axonal guidance signaling | 6.61 × 10−3 |
| 13 | Reelin Signaling in Neurons | 1.12 × 10−3 | HGF Signaling | 6.92 × 10−3 |
| 14 | Complement system | 1.55 × 10−3 | Pancreatic adenocarcinoma signaling | 7.76 × 10−3 |
| 15 | Glioma signaling | 1.58 × 10−3 | Ovarian cancer signaling | 7.94 × 10−3 |
| 16 | Aryl hydrocarbon receptor signaling | 1.78 × 10−3 | NF-κB signaling | 1.12 × 10−2 |
| 17 | Colorectal cancer metastasis signaling | 1.91 × 10−3 | UVA-induced MAPK signaling | 1.35 × 10−2 |
| 18 | Wnt/β-catenin signaling | 1.95 × 10−3 | HMGB1 signaling | 1.38 × 10−2 |
| 19 | PAK signaling | 2.29 × 10−3 | Leukocyte extravasation signaling | 1.45 × 10−2 |
| 20 | Macropinocytosis signaling | 2.34 × 10−3 | p53 signaling | 1.62 × 10−2 |
| 21 | Endothelin-1 signaling | 2.45 × 10−3 | NRF2-mediated oxidative stress response | 1.66 × 10−2 |
| 22 | Regulation of the Epithelial-mesenchymal transition pathway | 3.80 × 10−3 | RAR activation | 1.91 × 10−2 |
| 23 | Glioblastoma multiforme signaling | 4.27 × 10−3 | cAMP-mediated signaling | 1.95 × 10−2 |
| 24 | Agranulocyte adhesion and diapedesis | 4.37 × 10−3 | Xenobiotic metabolism signaling | 2.09 × 10−2 |
| 25 | Neuropathic pain signaling in dorsal horn neurons | 5.62 × 10−3 | Molecular mechanisms of cancer | 2.09 × 10−2 |
| 26 | Ovarian cancer signaling | 5.89 × 10−3 | MSP-RON signaling pathway | 2.95 × 10−2 |
| 27 | HIF1α signaling | 5.89 × 10−3 | Cardiac hypertrophy signaling | 3.16 × 10−2 |
| 28 | Caveolar-mediated Endocytosis Signaling | 6.03 × 10−3 | STAT3 pathway | 3.24 × 10−2 |
| 29 | Phagosome formation | 6.76 × 10−3 | Sphingosine-1-phosphate signaling | 3.39 × 10−2 |
| 30 | Role of tissue factor in cancer | 7.41 × 10−3 | LPS/IL-1 Mediated Inhibition of RXR function | 4.27 × 10−2 |
| 31 | Hmgb1 signaling | 1.07 × 10−2 | Role of pattern recognition Receptors in recognition of bacteria and viruses | 4.47 × 10−2 |
| 32 | Adipogenesis pathway | 1.15 × 10−2 | Prostanoid biosynthesis | 4.79 × 10−2 |
| 33 | Protein kinase a signaling | 1.17 × 10−2 | Coagulation system | 4.90 × 10−2 |
| 34 | NRF2-mediated oxidative stress response | 1.23 × 10−2 | ||
| 35 | Role of pattern recognition Receptors in recognition of bacteria and viruses | 1.26 × 10−2 | ||
| 36 | LPS/IL-1 mediated inhibition of RXR function | 1.38 × 10−2 | ||
| 37 | Growth hormone signaling | 1.38 × 10−2 | ||
| 38 | Paxillin signaling | 1.41 × 10−2 | ||
| 39 | Bladder cancer signaling | 1.45 × 10−2 | ||
| 40 | Xenobiotic metabolism signaling | 1.48 × 10−2 | ||
| 41 | Role of NFAT in cardiac hypertrophy | 1.55 × 10−2 | ||
| 42 | IL-8 signaling | 1.62 × 10−2 | ||
| 43 | Clathrin-mediated endocytosis signaling | 1.66 × 10−2 | ||
| 44 | Tec kinase signaling | 1.70 × 10−2 | ||
| 45 | HGF signaling | 1.74 × 10−2 | ||
| 46 | Agrin interactions at neuromuscular junction | 2.09 × 10−2 | ||
| 47 | PDGF signaling | 2.14 × 10−2 | ||
| 48 | Glioma invasiveness signaling | 2.19 × 10−2 | ||
| 49 | NF-κB signaling | 2.19 × 10−2 | ||
| 50 | eNOS signaling | 2.19 × 10−2 | ||
| 51 | Nitric oxide signaling in the cardiovascular system | 2.40 × 10−2 | ||
| 52 | MSP-RON signaling pathway | 2.45 × 10−2 | ||
| 53 | Sphingosine-1-phosphate signaling | 2.69 × 10−2 | ||
| 54 | UVA-induced MAPK signaling | 3.39 × 10−2 | ||
| 55 | IGF-1 signaling | 3.55 × 10−2 | ||
| 56 | Glucocorticoid receptor signaling | 3.55 × 10−2 | ||
| 57 | VEGF signaling | 3.72 × 10−2 | ||
| 58 | Prostanoid biosynthesis | 4.37 × 10−2 | ||
| 59 | Coagulation system | 4.37 × 10−2 | ||
| 60 | Ethanol degradation IV | 4.68 × 10−2 | ||
| 61 | TGF-β signaling | 4.68 × 10−2 | ||
| 62 | Germ cell-sertoli cell junction signaling | 4.68 × 10−2 | ||
| 63 | HER-2 signaling in breast cancer | 4.90 × 10−2 |
Canonical pathways were analyzed with Ingenuity Pathway Analysis (IPA) software
Pathways with p-values below 0.05 were selected
The numbers of pathways are shown in parentheses