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. 2019 Dec 2;10(12):905. doi: 10.1038/s41419-019-2140-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Representative scotopic ERG waves at different times after NMDA treatment. b Representative photopic ERG waves after 2 h of NMDA treatment. c Quantification of the b wave and PhNR amplitude at different time points of treatment. The standardized b-wave and PhNR of after injection of NMDA at the indicated times. 0.5, 1.0, 2.0, 4.0, and 6.0 h group, n = 9: 0.75 ± 0.06, P < 0.0001; 0.66 ± 0.14, P < 0.0001; 0.61 ± 0.11, P < 0.0001; 0.51 ± 0.15, P < 0.0001; 0.43 ± 0.08, P < 0.0001. d Example images of retinal flatmount preparations labeled with Brn3a (red). The number of labeled RGCs decreased significantly when treated with 0.05 mM NMDA for 6 h. (scale bar = 50 μm). e Quantification of the numbers of RGCs/mm². The RGCs number of NMDA 0.5 h, 1.0, 2.0, 4.0, and 6.0 h group, n = 9: 3326.48 ± 311.43, P = 0.65; 3280.18 ± 205.39, P = 0.51; 3264.32 ± 287.20, P = 0.72; 3028.12 ± 262.96, P = 0.07; 2686.90 ± 292.91, P = 0.0002.