Table 1.
Participants’ Characteristics
| Parameter | Normal | Glaucoma | Mean Difference (95% CI, P value) |
|
|---|---|---|---|---|
| Participants, n | 34 | 41 | ||
| Eyes, n | 34 | 41 | ||
| Age (Years) | 65.3 ± 8.9 | 64.9 ± 9.3 | −0.4 (−4.8~ 4.0, 0.853) | |
| Glaucoma drops. n (%) | 0 (0%) | 1.9 ± 0.8,41 (100%) | ||
| Intraocular Pressure (mm Hg) | 14.9 ± 3.6 | 15.1 ± 2.7 | 0.2 (−1.2~ 1.7, 0.767) | |
| Axial Length (mm) | 23.9 ± 1.2 | 24.3 ± 1.1 | 0.4 (−0.1~ 1.0, 0.830) | |
| Diastolic Blood Pressure (mm Hg) | 76.1 ± 16.0 | 77.4 ± 10.9 | 1.3 (−5.4~ 7.9, 0.702) | |
| Systolic Blood Pressure (mm Hg) | 121.9 ± 25.2 | 126.2 ± 15.9 | 4.3 (−6.1~ 14.5, 0.415) | |
| Mean Ocular Perfusion Pressure (mm Hg) | 46.1 ± 10.2 | 47.3 ± 6.9 | 1.3 (−3.0~ 5.4, 0.562) | |
| Visual Field | MD (dB) | 0.06 ± 1.16 (−3.22 ~ 1.87) | −4.77 ± 3.70 (−12.56~ −0.12) | −4.83 (−6.3~ −3.7, <0.001) |
| PSD (dB) | 1.42 ± 0.25 (1.02 ~ 2.17) | 6.20± 3.90 (1.51 ~ 14.24) | 4.78 (3.7~ 6.4, <0.001) | |
|
Structural OCT Thickness Measurement |
NFL (μm) | 97.9 ± 7.0 (85~111) | 77.5 ± 11.8 (57 ~100) | −20.4 (−25.0~ −15.8, <0.001) |
|
OCT Angiography Measurements (% area) |
Signal Strength Index | 69 ± 8 (54~89) | 64 ± 8 (50~84) | −5 (−9~ −1, <0.001) |
| NFLP-CD | 69.4 ± 4.8 (59.9~79.6) | 48.5 ± 12.9 (19.1~76.1) | −20.9 (−25.2~16.2, <0.001) | |
| GCLP-CD | 49.4 ± 5.6 (39.5~62.1) | 48.5 ± 5.5 (37.5~60.1) | −0.9 (−3.5~ 1.7, 0.477) | |
| SVC-CD | 77.4 ± 4.3 (69.7~86.3) | 62.4 ± 9.9 (37.4~85.5) | −15.0 (−18.6~−11.5, <0.001) | |
| DVC-CD | 48.4 ± 9.3 (29.4~65.1) | 48.5 ± 9.8 (29.6~66.8) | 0.1 (−4.3~ 4.4, 0.977) | |
| All-Plexus-CD | 89.3 ± 4.0 (83.0~95.8) | 79.4 ± 7.4 (58.7~96.6) | −9.9 (−12.6~ −6.9, <0.001) | |
| NFLP-VD | 75.7 ± 4.2 (67.0~83.9) | 57.6 ± 11.7 (33.0~82.1) | −18.1 (−22.4~−13.9, <0.001) | |
| SVC-VD | 82.5 ± 3.7 (75.8~89.5) | 70.2 ± 8.6 (49.2~89.8) | −12.3 (−15.5~ −9.2, <0.001) | |
Numbers displayed are mean ± standard deviation (range); CI = confidence interval, MD = mean deviation, PSD = pattern standard deviation, NFL = nerve fiber layer, CD = capillary density, VD = vessel density, NFLP = nerve fiber layer plexus, GCLP = ganglion cell layer plexus, SVC = superficial vascular complex, DVC = deep vascular complex.