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Effects of endogenous human mitochondrial transcription factor A (hTFAM) overexpression in human cells. HeLa cells were engineered with rv.2739 and lv.3775 for doxycycline-regulated expression of hTFAM cDNA, and mitochondrial parameters were followed during induction. (A) hTFAM transcript. (B) mtDNA transcripts. (C) Protein levels. (D) mtDNA content. (E) Mitochondrial mass. *p < 0.05; **p < 0.01; ***p < 0.001.
