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. 2019 Nov 27;12:10299–10309. doi: 10.2147/OTT.S210014

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© 2019 Huang et al.

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NOK-mediated activation of Akt/GSK-3β pathway in NSCLC cell lines. (A, B) NOK/p-Akt (Thr308; Ser473)/p-GSK-3β (Ser9)/N-cadherin was overexpressed in A549 cells compared to SPC-A-1 cells. *P<0.05. (C) Protein expression of NOK, p-Akt (Ser473, Thr308), p-GSK3β (Tyr216, Ser9), E-cadherin and N-cadherin by Western blotting of A549 and SPC-A-1 NSCLC cell lines transfected with STYK1-OE lentivirus and NC lentivirus. (D) Protein expression of NOK, p-Akt (Ser473, Thr308), p-GSK3β (Tyr216, Ser9), E-cadherin and N-cadherin by Western blotting of A549 NSCLC cell line transfected with two STYK1-shRNAs and one NC shRNA.