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The fibrillin-1 sequence is composed predominantly by 47 EGF-like domains, 43 that are Ca2+ binding. The repeating structural domains of fibrillin-1 are defined at the top of the figure. The fragment cbEGF19–cbEGF25, containing the 4th TB repeat, was purified in a human mammalian system using the adjoining His tag. The amino acid sequence for part of domain TB4 denotes the location of the RGD domain and the subsequent tryptophan that is mutated in the SSS background.
