Figure 1.

Schematic of 4R tau protein depicting major structural domains. tau is an MT-associated protein that consists of an N-terminal region, a proline-rich domain, an MTBD composed of four MT-binding repeats in the 4R isoforms, and a C-terminal region. Indicated are the locations of the pathogenic tau missense mutants that were investigated herein; they were numbered relative to the longest 2N4R tau isoform expressed in the human brain. Most tau missense mutants are clustered within the MTBD.