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. 2019 Oct 10;142(12):3892–3905. doi: 10.1093/brain/awz303

Figure 4.

Figure 4

Synchronizability provides novel clinical information. (A) Our model correctly predicted HUP073 to be seizure-free after surgery. A board-certified epileptologist determined there is no DC shift, low voltage fast activity, or clearly focal seizure onset. This stereotyped clinical seizure results in arousal from sleep without evident EEG change. While the clinically marked seizure onset began with an arousal pattern in LLT04–06, here rhythmic activity begins in ROF1–3 60 s into seizure, later progressing to RLT1–3. Resection was performed in the right frontal region. Synchronizability decreases throughout the seizure in this patient, predicting seizure freedom after surgery. (B) Our model correctly predicted the poor outcome of Patient HUP080. In the displayed seizure, a board-certified epileptologist determined seizure onset electrodes of AST1–3 with the presence of low voltage fast activity (red box), and a clearly focal seizure onset but no DC shift. Synchronizability increases after earliest electrographic change (EEC) in this patient, correctly predicting the surgical outcome of this patient to be poor.