Table V. Decision ruleset applied in the original TPP analysis workflow [6] to combine z-test p values across replicates in an experimental design with two biological replicates.

Rule number	Rule
1	The Benjamini-Hochberg adjusted z-test p values fulfill predefined thresholds in each replicate.
2	Both Tm differences are either positive or negative in the two biological replicates.
3	The smallest absolute difference between treatment and vehicle Tm is greater than the absolute Tm difference between the two vehicle experiments.