Figure 2.

Amelioration of thermal perception threshold in planta pedis of diabetic rats treated with ranirestat. Thermal perception threshold increased in the diabetic rats 12 weeks after induction of diabetes. The increase was diminished in the diabetic rats after 6-week treatment with ranirestat. N: nondiabetic rats; D: diabetic rats; veh: rats treated with placebo; rani: rats treated with ranirestat; epa: rats treated with epalrestat. ^∗p < 0.05 compared with N or nondiabetic vehicle and ^##p < 0.005 compared with diabetic vehicle. n = 15~18 at 12 w, n = 8~10 in groups treated with placebo or ranirestat, and n = 3 in rats treated with epalrestat. Bold horizontal line in each group demonstrates an average value.