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. 2019 Nov 18;2019:2756020. doi: 10.1155/2019/2756020

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Copyright © 2019 Saeko Asano et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Intraepidermal nerve fiber density (IENFD) after the treatment with ranirestat. (a) Representative photos of IENFs in diabetic rats treated with or without ranirestat. (b) Quantification of the IENFD revealed a significant decrease in untreated diabetic rats and the significant amelioration by ranirestat treatment. N: nondiabetic rats; D: diabetic rats; veh: rats treated with placebo; rani: rats treated with ranirestat. ^∗p < 0.05 versus N treated with placebo, ^†p < 0.05 versus D treated with ranirestat, and n = 6–8 in each group. Scale bar: 50 μm.