Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Dec 2;29(6):323–334. doi: 10.1089/nat.2019.0815

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Zhongtian Liu et al. 2019; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

FIG. 2. — Diagram of the small RNA systems used to evaluate TNRC6 involvement in RNAi processes. (A) AGO2 loaded with siATX-3 targets and cleaves ATX-3 mRNA causing siRNA knockdown of ATX-3 in the cytoplasm. (B) AGO2 loaded with siMalat1 targets and cleaves Malat1 ncRNA causing siRNA knockdown of Malat1 in the nucleus. (C) AGO2 loaded with a small RNA binds to a sense transcript that overlaps the COX-2 promoter. This causes further activation of gene transcription. (D) AGO2 loaded with miR34a targets and causes the degradation of Sirt1 mRNA. This causes the activation of P53 and apoptosis. ATX-3, ataxin-3; COX-2, cyclooxygenase-2; mRNA, messenger RNA; miRNA, microRNA; ncRNA, noncoding RNA; RNAi, RNA interference; siRNA, small interfering RNA.