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Role of MYOF in EGFR-related pathway. MYOF gene is induced by MKL1/2 and SRF. MYOF directs p-EGFR to lysosome degradation and shuts off EGFR related signaling. Inhibition of MYOF leads to continuous phosphorylated EGFR, which further activates Ras/MEK/ERK and results in Oncogene-induced senescence.
