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. 2019 Nov 18;2019:1036907. doi: 10.1155/2019/1036907

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Copyright © 2019 Еlena V. Mitroshina et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Mitochondrial functional activity in primary hippocampal cell cultures one day after acute normobaric hypoxia modelling in vitro. (a) The rate of oxygen consumption by mitochondria in the V4 state (glutamate and malate substrates). (b) The rate of oxygen consumption by mitochondria in the V3 state (glutamate and malate substrates, ADP). (c) The rate of oxygen consumption by mitochondria in the V4 state (succinate substrate). (d) The degree of mitochondrial respiratory chain coupling (V3/V4 ratio). The data represent the mean values ± SEMs from three independent experiments. Statistical significance was calculated by one-way ANOVA; p < 0.05; ^∗versus “Sham”; ^#versus “Hypoxia”.