Table 2.
Analysis of cell viability in primary hippocampal cultures under the inhibition of intracellular kinases in hypoxia modelling.
| Group | Number of viable cells on day 7 after inhibitor application (%) | Number of viable cells on day 7 after inhibitor and GDNF application (%) |
|---|---|---|
| Sham | 92.28 ± 1.81 | |
| Hypoxia | 72.05 ± 5.73∗ | |
| Hypoxia+GDNF | 87.78 ± 4.63∗# | |
| Hypoxia+RET kinase inhibitor | 30.03 ± 1.96∗# | 28.27 ± 1.57∗#& |
| Hypoxia+RAF kinase inhibitor | 74.48 ± 2.89∗ | 80.09 ± 2.18∗ |
| Hypoxia+MAP2K1/2, Erk2, RAF kinase inhibitor | 79.03 ± 3.64∗ | 81.21 ± 4.19# |
| Hypoxia+AKT1 kinase inhibitor | 70.22 ± 3.61∗ | 77.96 ± 2.02∗#& |
| Hypoxia+Jak1, Jak2 kinase inhibitor | 74.52 ± 3.61∗ | 75.22 ± 5.61∗& |
The data represent the mean values ± SEMs from six independent experiments. Statistical significance was calculated by one-way ANOVA; ∗versus “Sham”; #versus “Hypoxia”; &versus “Hypoxia+GDNF”.