(a).
| Valid | Primary resected tumor | Lymph node metastasis | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LGR5 score 0-6 | MIST1 score 0-6 | |||||||||||
| Low (0-4) | High (5-6) | Negative (0) | Positive (2-6) | |||||||||
| n | (%) | n | (%) | n | (%) | n | (%) | n | (%) | |||
| Gender | n | p (1) | 101 | 0.797 | 64 | 0.728 | ||||||
| Male | 95 | (79.8) | 47 | (56.6) | 36 | (43.4) | 32 | (59.3) | 22 | (40.7) | ||
| Female | 24 | (20.2) | 11 | (61.1) | 7 | (38.9) | 7 | (70.0) | 3 | (30.0) | ||
| Age | n | p (1) | 101 | 0.423 | 64 | 0.204 | ||||||
| <64 years | 60 | (50.4) | 31 | (62.0) | 19 | (38.0) | 24 | (68.6) | 11 | (31.4) | ||
| ≥64 years | 59 | (49.6) | 27 | (52.9) | 24 | (47.1) | 15 | (51.7) | 14 | (48.3) | ||
| Laurén | n | p (1) | 101 | 0.100 | 64 | 0.951 | ||||||
| Intestinal | 52 | (43.7) | 30 | (61.2) | 19 | (38.8) | 17 | (63.0) | 10 | (37.0) | ||
| Diffuse | 25 | (21.0) | 17 | (70.8) | 7 | (29.2) | 9 | (64.3) | 5 | (35.7) | ||
| Mixed | 18 | (15.1) | 8 | (44.4) | 10 | (55.6) | 8 | (57.1) | 6 | (42.9) | ||
| Unclassifiable | 14 | (11.8) | 3 | (30.0) | 7 | (70.0) | 5 | (55.6) | 4 | (44.4) | ||
| Complete regression | 10 | (8.4) | ||||||||||
| Localization | n | p (1) | 101 | 0.099 | 64 | 0.188 | ||||||
| Proximal | 74 | (62.2) | 32 | (50.8) | 31 | (49.2) | 23 | (54.8) | 19 | (45.2) | ||
| Distal | 45 | (37.8) | 26 | (68.4) | 12 | (31.6) | 16 | (72.7) | 6 | (27.3) | ||
| ypT category | n | p (2) | 101 | 0.020 | 64 | 0.029 | ||||||
| ypT0 | 13 | (10.9) | 3 | (100.0) | 0 | (0.0) | ||||||
| ypT1a/T1b | 19 | (16.0) | 13 | (76.5) | 4 | (23.5) | 1 | (50.0) | 1 | (50.0) | ||
| ypT2 | 15 | (12.6) | 10 | (66.7) | 5 | (33.3) | 9 | (81.8) | 2 | (18.2) | ||
| ypT3 | 63 | (52.9) | 32 | (53.3) | 28 | (46.7) | 24 | (57.1) | 18 | (42.9) | ||
| ypT4a/T4b | 9 | (7.6) | 3 | (33.3) | 6 | (66.7) | 2 | (33.3) | 4 | (66.7) | ||
| ypN category | n | p (2) | 101 | 0.015 | 64 | 0.004# | ||||||
| ypN0 | 44 | (37.0) | 22 | (71.0) | 9 | (29.0) | ||||||
| ypN1 | 27 | (22.7) | 17 | (68.0) | 8 | (32.0) | 18 | (81.8) | 4 | (18.2) | ||
| ypN2 | 25 | (21.0) | 9 | (39.1) | 14 | (60.9) | 13 | (61.9) | 8 | (38.1) | ||
| ypN3 | 23 | (19.3) | 10 | (45.5) | 12 | (54.5) | 8 | (38.1) | 13 | (61.9) | ||
| M category | n | p (1) | 101 | 0.797 | 64 | 1.000 | ||||||
| M0 | 98 | (82.4) | 47 | (56.6) | 36 | (43.4) | 32 | (61.5) | 20 | (38.5) | ||
| M1 | 21 | (17.6) | 11 | (61.1) | 7 | (38.9) | 7 | (58.3) | 5 | (41.7) | ||
| UICC stage | n | p (2) | 101 | 0.283 | 64 | 0.099 | ||||||
| 0/0/N+ | 12 | (10.1) | 2 | (100.0) | 0 | (0.0) | ||||||
| IA/IB | 19 | (16.0) | 13 | (72.2) | 5 | (27.8) | 0 | (0) | 0 | (0) | ||
| IIA/IIB | 21 | (17.6) | 13 | (61.9) | 8 | (38.1) | 9 | (90.0) | 1 | (10.0) | ||
| IIIA/IIIB/IIIC | 46 | (38.7) | 21 | (47.7) | 23 | (52.3) | 21 | (52.5) | 19 | (47.5) | ||
| IV | 21 | (17.6) | 11 | (61.1) | 7 | (38.9) | 7 | (58.3) | 5 | (41.7) | ||