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. 2019 Nov 18;2019:2382534. doi: 10.1155/2019/2382534

Figure 3.

Figure 3

HIF-1α-related pathway. (a) RNA-sequencing results for glycolytic genes and HIF-1α; relative transcript expression between D-MG and MG for HIF-1α and its downstream targets (b) on tricarboxylic cycle (TCA) and (c) on glycolysis and extracellular matrix (ECM) production. ∗ indicates p < 0.05 (n = 3). (d) Validation of glycolytic genes using RT-PCR. ∗ indicates p < 0.05 (n = 3). (e) Schematic diagram showing the major changes in D-MG versus MG for HIF-1α signaling: D-MG shows enhanced HIF-1α activities that reduce TCA and ATP production, increasing glycolysis mediated by HIF-1α.