Table 2.
The ORs (95% CI) for breast cancer at advanced stage vs early stage according to major clinical and pathological characteristics
| Characteristics | Early stage | Advanced stage | Age‐adjusted OR (95% CI) | P‐value | Multivariate‐adjusted OR (95% CI)a | P‐value |
|---|---|---|---|---|---|---|
| Menopausal statusb | ||||||
| Premenopausal status | 262 (53.6%) | 290 (49.0%) | 1.00 | 1.00 | ||
| Postmenopausal status | 227 (46.4%) | 302 (51.0%) | 1.45 (1.02‐2.05) | .02 | 1.53 (1.06‐2.19) | .02 |
| Age at menopausec | ||||||
| Age at menopause <50 y | 91 (40.6%) | 99 (35.4%) | 1.00 | 1.00 | ||
| Age at menopause 50‐55 y | 114 (50.9%) | 159 (56.8%) | 1.12 (0.76‐1.65) | .57 | 1.12 (0.74‐1.68) | .59 |
| Age at menopause ≥55 y | 19 (8.5%) | 22 (7.8%) | 0.84 (0.42‐1.70) | .64 | 0.95 (0.45‐1.98) | .88 |
| P trend | .92 | .78 | ||||
| History of abortion | ||||||
| Never | 309 (63.3%) | 465 (80.9%) | 1.00 | 1.00 | ||
| Had | 179 (36.7%) | 110 (19.1%) | 0.39 (0.30‐0.52) | <.0001 | 0.37 (0.28‐0.50) | <.0001 |
| History of spontaneous abortiond | ||||||
| Never | 351 (72.2%) | 508 (91.4%) | 1.00 | 1.00 | ||
| Had | 135 (27.8%) | 48 (8.6%) | 0.23 (0.16‐0.33) | <.0001 | 0.22 (0.15‐0.31) | <.0001 |
| History of induced abortiond | ||||||
| Never | 442 (90.9%) | 504 (90.6%) | 1.00 | 1.00 | ||
| Had | 44 (9.1%) | 52 (9.4%) | 1.07 (0.70‐1.64) | .76 | 1.06 (0.68‐1.65) | .79 |
| Breast density | ||||||
| I (Fatty) | 22 (6.6%) | 16 (4.0%) | 0.66 (0.32‐1.37) | .27 | 0.68 (0.32‐1.46) | .33 |
| II (Scattered) | 94 (28.2%) | 99 (24.6%) | 1.00 | 1.00 | ||
| III (Heterogeneous) | 207 (62.2%) | 257 (63.9%) | 1.16 (0.81‐1.65) | .42 | 1.25 (0.86‐1.82) | .23 |
| IV (Extreme) | 10 (3.0%) | 30 (7.5%) | 2.59 (1.18‐5.68) | .02 | 2.57 (1.14‐5.79) | .02 |
| P trend | .02 | .01 | ||||
| Tumor location | ||||||
| Upper outer quadrant | 152 (31.1%) | 245 (40.6%) | 1.00 | 1.00 | ||
| Lower outer quadrant | 94 (19.3%) | 101 (16.7%) | 0.68 (0.48‐0.97) | .04 | 0.67 (0.47‐0.98) | .04 |
| Upper inner quadrant | 93 (19.1%) | 88 (14.6%) | 0.59 (0.41‐0.84) | .004 | 0.60 (0.41‐0.87) | .01 |
| Lower inner quadrant | 21 (4.3%) | 26 (4.3%) | 0.84 (0.45‐1.58) | .59 | 1.00 (0.51‐1.94) | 1.00 |
| Central zone | 128 (26.2%) | 143 (23.8%) | 0.70 (0.51‐0.96) | .03 | 0.70 (0.50‐0.98) | .04 |
| ER | ||||||
| + | 320 (74.8%) | 183 (67.5%) | 1.00 | 1.00 | ||
| ‐ | 108 (25.2%) | 88 (32.5%) | 1.47 (1.05‐2.06) | .03 | 1.37 (0.96‐1.97) | .09 |
| PR | ||||||
| + | 285 (67.1%) | 155 (57.4%) | 1.00 | 1.00 | ||
| ‐ | 140 (32.9%) | 115 (42.6%) | 1.56 (1.13‐2.14) | .01 | 1.43 (1.02‐2.02) | .04 |
| HER2 | ||||||
| ‐ | 246 (62.8%) | 121 (48.4%) | 1.00 | 1.00 | ||
| + | 146 (37.2%) | 129 (51.6%) | 1.81 (1.31‐2.52) | .0004 | 1.83 (1.29‐2.59) | .0007 |
| Ki‐67 | ||||||
| <14% | 86 (20.2%) | 37 (14.0%) | 1.00 | 1.00 | ||
| ≥14% | 339 (79.8%) | 227 (86.0%) | 1.62 (1.05‐2.49) | .03 | 1.58 (1.00‐2.50) | .05 |
Abbreviations: CI, confidence interval; OR, odds ratio; SD, standard deviation.
Unless otherwise noted, multivariable‐adjusted analyses were conducted including age (continuous variable), menopausal status and age at menopause (premenopausal, age at menopause <50 y, age at menopause 50‐55, or age at menopause ≥55 y), history of abortion (never or had), breast density (I, II, III, or IV), and tumor location (upper outer quadrant, lower outer quadrant, upper inner quadrant, lower inner quadrant, or central zone) in the model.
All covariates as listed in footnote (a) but menopausal status and age at menopause were adjusted for.
Analyses were conducted only in postmenopausal women.
All covariates as listed in footnote (a) but history of abortion was adjusted for.