Figure 1.

Zinc ribbon domain‐containing 1 (ZNRD1) is upregulated in hepatocellular carcinoma (HCC) tissues and predicts a poor prognosis. A, ZNRD1 expression in 8 paired HCC tissues and adjacent noncancer tissues was analyzed by western blot. B, Representative image of ZNRD1 IHC staining in HCC TMA cohort with different staining scores. Images were presented at 40× magnification (up panel) or 200× magnification (lower panel). C, Distribution of ZNRD1 IHC staining scores in HCC tissues or paired noncancer tissues. Images are presented at 40× magnification. D and E, Representative images of ZNRD1 IHC staining and distribution of ZNRD1 IHC staining scores in HCC tissues with different TNM stage, with or without lymph node metastasis. F, Kaplan‐Meier analysis of overall survival in patients with variable ZNRD1 expression. G, Univariate analysis of the association between ZNRD1 expression and different clinicopathological features. **P < .01 based on the nonparametric test