Figure 6.

Zinc ribbon domain‐containing 1 (ZNRD1) is a direct target of miR‐26b in hepatocellular carcinoma (HCC) cells. A and B, The expression level of miR‐26b in HCC and nontumor normal tissues was analyzed in TCGA and ZZU cohort. C, The relative luciferase activities were detected in 293T cells transfected with ZNRD1 wild‐type and mutant type plasmids based on a dual‐luciferase reporter assay. D‐F, The expression levels of ZNRD1 mRNA (D, E) or protein (F) in SMMC‐7721 or Hep 3B cells transfected with miR‐26b mimic, miR‐26b inhibitor or negative ctrl were analyzed by qRT‐PCR or western blot. G, Pearson correlation analysis of the miR‐26b expression and ZNRD1 expression in HCC tissues. **P < .01