Table 2.

Correlation of clinicopathological features with ZNRD1 expression in ZZU HCC cohort

	Univariate analysis			Multivariate analysis
	HR	95% CI	P value	HR	95% CI	P value
Age (>50 vs ≤50)	1.143	0.884‐1.413	.863
Gender (Female vs ≤ Male)	0.846	0.534‐1.342	.479
Pathogenesis (Virus vs ≤Others)	0.784	0.341‐1.341	.243
AFP (>20 vs ≤20)	1.270	0.684‐1.654	.347
Child‐Pugh (C vs A&B)	1.814	1.491‐2.765	.029	1.468	1.271‐2.007	.247
Cirrhosis (Present vs Absent)	1.515	0.812‐2.825	.192
Vascular invasion (Present vs Absent)	1.848	1.225‐2.793	.003	2.489	1.749‐3.015	.022
TNM stage (III & IV vs I & II)	3.333	2.262‐4.902	.000	4.158	3.029‐5.489	.007
Tumor size (>5 vs ≤5)	1.751	1.198‐2.564	.004	1.249	1.011‐1.698	.227
Tumor multiplicity (Multiple vs Single)	2.964	2.176‐3.472	.019	2.146	1.769‐2.465	.037
ZNRD1 expression (High vs Low)	2.765	2.102‐3.475	.034	3.125	2.498‐4.836	.024

Bold values indicate statistical significance, P < 0.05