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. 2019 Nov 28;25(44):6495–6507. doi: 10.3748/wjg.v25.i44.6495

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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

PMC Copyright notice

MicroRNA 375 regulates metadherin-mediated NFKB1 signaling in colorectal cancer cell lines. Western blot analysis of NF-κB inhibitor alpha (NFKBIA), NFKB1 (p50), and RELA (p65) expression levels in colorectal cancer (CRC) cells. A: NFKBIA expression levels were upregulated on microRNA 375 (MIR375) mimic and siMTDH transfection in HCT116 cells; B: NFKBIA expression levels were upregulated on MIR375 mimic and siMTDH transfection in Caco2 cells; C: NFKB1 and RELA levels were downregulated on MIR375 mimic and siMTDH transfection in HCT116 cells; D: NFKB1 and RELA levels were downregulated on MIR375 mimic and siMTDH transfection in Caco2 cells. Four independent experiments were performed with duplicates and P values were calculated using Student’s t-test (^aP < 0.05, ^bP < 0.01). MTDH: Metadherin; MIR375: MicroRNA 375; NFKBIA: NF-κB inhibitor alpha; CRC: Colorectal cancer.