Table 1.

Frequency of gene mutations in AA, R-CRC, and L-CRC.

Gene	AA N = 183	R-CRC N = 994	L-CRC N = 1080	P value a	P value a	P value a
	%	%	%	AA vs. R-CRC	AA vs. L-CRC	R-CRC vs. L-CRC
TP53	40	66*	75*	<0.001	<0.001	<0.001
GNAS	31	2*	1*	<0.001	<0.001	0.049
SMAD4	16	11*	10*	0.042	0.029
APC	10	70*	83*	<0.001	<0.001	<0.001
PIK3CA	6	22*	17*	<0.001	<0.001	0.008
FBXW7	3	11*	9*	0.002	0.015
NRAS	1	3*	5*	0.048	0.004
AMER1	0	9*	2*	<0.001	0.024	<0.001
ARID1A	8	26*	19	0.006		0.034
BRAF	5	17*	5	<0.001		<0.001
ATM	2	7*	5	0.012		0.041
KMT2D	2	7*	2	0.006		<0.001
PTEN	1	8*	3	<0.001		<0.001
MSH6	1	5*	2	0.016		<0.001
HNF1A	1	5*	1	0.024		<0.001
PTCH1	1	5*	1	0.009		<0.001
CTNNB1	0	4*	1	0.004		0.001
KRAS	55	56	43*		0.004	<0.001
RNF43	7	11	2*		0.004	<0.001

^aP value was based on Fisher’s exact test. Blanks are P > 0.05.

^*P < 0.05 compared to AA.

AA, appendiceal adenocarcinoma; L-CRC, left-sided colorectal cancer; R-CRC, right-sided colorectal cancer.