Table 2.
Frequency of gene mutations in the histopathological subtypes of AA.
| Gene | NOS n = 46 |
PMP n = 66 |
MU n = 44 |
SR n = 27 |
P value a | P value a | P value a |
|---|---|---|---|---|---|---|---|
| % | % | % | % | NOS vs. PMP | NOS vs. MU | NOS vs. SR | |
| KRAS | 44 | 74* | 64 | 15* | 0.002 | 0.019 | |
| GNAS | 7 | 63* | 25* | 4 | <0.001 | 0.020 | |
| TP53 | 51 | 23* | 57 | 33 | 0.004 | ||
| SMAD4 | 15 | 15 | 20 | 11 | |||
| RNF43 | 9 | 6 | 7 | 4 | |||
| APC | 22 | 2* | 16 | 0* | <0.001 | 0.011 | |
| PIK3CA | 15 | 2* | 7 | 0* | 0.009 | 0.042 | |
| BRAF | 7 | 0 | 9 | 7 | |||
| ARID1A | 11 | 0 | 15 | 11 |
a
P value was based on Fisher’s exact test. Blanks are P > 0.05.
*
P < 0.05 compared to NOS.
AA, appendiceal adenocarcinoma; L-CRC, left-sided colorectal cancer; MU, mucinous adenocarcinoma; NOS, adenocarcinoma, not otherwise specified; PMP, pseudomyxoma peritonei; R-CRC, right-sided colorectal cancer; SR, signet ring cell carcinoma.