Table 4.
Univariate Analysis of Patient Variables in Response to Therapy
| Variable | CR/PR | SD/PD | P Value |
|---|---|---|---|
| Patients (n) | 15 | 13 | |
| Age (years) | .6600a | ||
| Median | 71 | 67 | |
| Range | 47–82 | 52–89 | |
| Sex | .6891b | ||
| Female | 4 (26.7) | 5 (38.5) | |
| Male | 11 (73.3) | 8 (61.5) | |
| Cycles | .1066a | ||
| Median | 4 | 3 | |
| Range | 3–14 | 2–12 | |
| Primary | .886b | ||
| Bladder | 5 (33.3) | 6 (46.2) | |
| Renal pelvis | 6 (40.0) | 5 (38.5) | |
| Ureter | 4 (26.7) | 2 (15.4) | |
| Previous therapy | .4757b | ||
| 1 | 8 (53.3) | 5 (38.5) | |
| 2 | 7 (46.7) | 8 (61.5) | |
| Metastatic sites | |||
| Lymph nodes | 13 (86.7) | 8 (61.5) | .1977b |
| Lung | 6 (40) | 7 (53.9) | .7051b |
| Liver | 5 (33.3) | 2 (15.4) | .3955b |
| Bone | 3 (20) | 2 (15.4) | 1.0000b |
| Interval from last chemotherapy | .1283b | ||
| <3 mo | 5 (33.3) | 9 (69.2) | |
| ≥3 mo | 10 (66.7) | 4 (30.8) | |
| Screening ECOG PS | .0238b | ||
| 0 | 9 (60.0) | 2 (15.4) | |
| 1 | 6 (40.0) | 11 (84.6) | |
| Bellmunt score | .0905b | ||
| 0 | 6 (40.0) | 1 (7.7) | |
| 1 | 4 (26.7) | 8 (61.5) | |
| 2 | 5 (33.3) | 4 (30.8) |
Data presented as n (%), unless otherwise noted.
Abbreviations: CR = complete response; ECOG = Eastern Cooperative Oncology Group; PD = progressive disease; PR = partial response; PS = performance status; SD = stable disease.
a
Wilcoxon rank sum test.
b
Fisher’s exact test.