Table 4.
U3–1565 Plasma PK Parameters in Part 2, Cycle 1 and Cycle 3
| Cycle 1 | Cycle 3 | |
|---|---|---|
| n | 21 | 21 |
| Cmax (μg/mL) | 486 (141) | 1121 (328) |
| tmax (h) | 3.93 (1.00–7.00) | 6.72 (0.97–74.4) |
| AUCtau (mg h/mL)# | 44.7 (11.8) | 147 (38.3) |
| Half-life (h)#* | 163 (60.8) | 469 (290) |
#
PK parameters are based on time points collected over 1 week.
*
Half-life was only evaluable for 15 subjects in Cycle 1, and for 10 subjects in Cycle 3. Mean (standard deviation) is reported above. For tmax, median (min, max) is reported. n = number of subjects