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. Author manuscript; available in PMC: 2020 Feb 7.
Published in final edited form as: Sci Transl Med. 2019 Aug 7;11(504):eaav3505. doi: 10.1126/scitranslmed.aav3505

Table 1. Summary of key MCC measures.

ICC: Intraclass correlation. PCL: Periciliary liquid layer depth; MCT: Mucociliary transport rate; CBF: Ciliary beat frequency; ASL: Airway surface liquid layer depth; ET: Epithelium thickness; pCC: Percent cilia coverage.

Metric non-CF CF P-value Measure-
ment
success
rate (%)
ICC for
intra-
observer
reliability
ICC for
inter-
observer
reliability

mean 95% CI mean 95% CI
PCL (μm) 6.9 6.1–7.6 5.6 5.2–6.0 <0.01 95 0.9866 0.8844
MCT (mm/min) 11.2 9.3–13.1 5.1 3.3–7.0 <0.0001 80 0.9994 0.9895
CBF (Hz) 14.4 13.7–15.2 11.7 9.4–13.9 <0.05 95 0.9752 0.9505
ASL (μm) 41.4 17.0–65.8 45.9 20.9–70.9 0.7537 70 0.9977 0.9982
ET (μm) 81.3 70.6–92.0 75.4 69.8–81.0 0.3127 100 0.9972 0.9927
pCC (%) 72.1 52.5–91.6 38.2 20.0–56.5 <0.05 100 0.9998 0.9985