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. 2019 Nov 21;9(12):2159–2169. doi: 10.1002/2211-5463.12759

Figure 4.

Figure 4

Platelet microvesicles from patients with cancer promote cancer cell migration by delivering TPM3 mRNA. (A) The mRNA level of TPM3 in platelets and platelet microvesicles (platelet‐mv) from 10 normal individuals and 10 patients with BC. (B) The mRNA level of TPM3 in MDA231 cells exposed to platelet microvesicles from healthy volunteers and patients with cancer. (C, D) The protein level of TPM3 in MDA231 cells exposed to platelet microvesicles from healthy volunteers and patients with cancer. (C) Representative image. (D) Quantitative analysis. (E, F) Platelet microvesicles from patients with cancer promote cancer cell migration. (E) Representative image (scale bars: 50 μm). (F) Quantitative analysis. Data are shown as the means ± standard error of the mean (n = 3). Statistical analysis was performed by two‐tailed Student’s t‐test; **P < 0.01, ***P < 0.001.