Table 2.
Hematological and biochemical changes recorded during the toxicity study in Swiss Albino mice. Values are mean ± SD. ALKP, alkaline phosphatase; RBC, red blood cells; SGOT, serum glutamate–oxaloacetate transaminase; SGPT, serum glutamate–pyruvate transaminase; WBC, white blood cells.
| Parameters | Uninfected | Infected with MTCC‐96 | ||
|---|---|---|---|---|
| Control | UA + Nor | Control | UA + Nor | |
| Change in body weight (g) | 3.64 ± 0.38 | 4.36 ± 0.44 | −3.33 ± 0.31 | −2.26 ± 0.27 |
| Relative organ weight | ||||
| Liver | 1.453 ± 0.19 | 2.115 ± 0.24 | 1.414 ± 0.27 | 1.178 ± 0.28 |
| Spleen | 0.556 ± 0.42 | 1.152 ± 0.30 | 1.257 ± 0.22 | 1.097 ± 0.5 |
| SGPT (U·L−1) | 7.15 ± 0.54 | 6.95 ± 0.63 | 6.835 ± 0.49 | 6.874 ± 0.31 |
| SGOT (U·L−1) | 10.96 ± 0.66 | 11.08 ± 0.38 | 12.36 ± 0.74 | 13.05 ± 0.63 |
| Serum creatinine (mg·dL−1) | 0.14 ± 0.08 | 0.17 ± 0.27 | 0.15 ± 0.18 | 0.16 ± 0.11 |
| Serum ALKP (U·L−1) | 118.04 ± 3.18 | 120.27 ± 2.21 | 114.39 ± 1.76 | 117.64 ± 2.91 |
| Serum total cholesterol (mg·dL−1) | 61.42 ± 2.09 | 57.92 ± 2.16 | 63.37 ± 1.88 | 65.69 ± 3.13 |
| Serum bilirubin (mg·dL−1) | 0.07 ± 0.017 | 0.06 ± 0.005 | 0.07 ± 0.004 | 0.08 ± 0.013 |
| Serum triglycerides (mg·dL−1) | 28.74 ± 3.74 | 31.36 ± 2.58 | 29.49 ± 2.14 | 31.33 ± 1.76 |
| RBC (millions·mm−3) | 4.532 ± 0.56 | 5.971 ± 0.29 | 6.059 ± 0.4 | 6.114 ± 0.28 |
| WBC (millions·mm−3) | 8.15 ± 0.56 | 12.22 ± 0.49 | 11.4 ± 0.27 | 12.23 ± 0.53 |
| Hemoglobin (g·dL−1) | 12.96 ± 0.35 | 12.14 ± 0.28 | 11.175 ± 1.04 | 11.54 ± 0.82 |