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. Author manuscript; available in PMC: 2019 Dec 3.
Published in final edited form as: Brain Behav Immun. 2018 Dec 11;76:248–257. doi: 10.1016/j.bbi.2018.12.005

Fig 3. CAS led to priming of hippocampal IL1B gene expression in female rats only.

Fig 3.

Male and female rats of NS or CAS backgrounds received a single systemic injection of saline or LPS in adulthood to unmask potential immune priming due to stressor exposure (n = 5–7/group). Targeted qPCR experiments confirmed that LPS led to a significant mRNA induction of all three cytokines (p<0.001) in the hippocampus. While there was no main effect of CAS, sex and CAS interacted such that CAS exaggerated hippocampal mRNA expression of A) IL1B in female (p=0.032, #), but not male, rats (p>0.05). CAS did not impact the mRNA expression of B) IL6 or C) TNF in the hippocampus of either males or females (p>0.05). Data are presented as mean fold change ± SEM. # main effect of CAS within females.