Fig 6. CAS leads to enhanced plasma IL-1β in males following LPS.
Male and female rats of NS or CAS backgrounds received a single systemic injection of saline or LPS in adulthood to unmask potential immune priming due to stressor exposure (n = 5–7/group). Plasma cytokine concentrations were analyzed with sex, stress, and LPS as main factors. While LPS led to a significant induction of all three cytokines (p<0.001) in plasma, sex did not impact cytokine concentrations (p>0.05). CAS males displayed greater plasma IL-1β compared to NS males at 4 hours post-LPS (p=0.017, *). Data are presented as mean ± SEM. * CAS effect across the indicated comparison.