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. 2019 Nov 25;7:798. doi: 10.3389/fchem.2019.00798

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Copyright © 2019 Ferreira, Pauli, Sampaio, de Souza, Ferreira, Magalhães, Rezende, Ferreira, Krogh, Dias and Andricopulo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Activity of the series of analogs featuring modifications in the imide nucleus against cruzain. ^aPercent inhibition against cruzain at 100 μM corresponding to the mean of three measurements. ^bIC₅₀ values against cruzain, which were independently determined by obtaining rate measurements in triplicate for at least six inhibitor concentrations. The IC₅₀ values represent the mean ± SD of three individual experiments. ND, IC₅₀ not determined.