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. 2019 Nov 25;10:2719. doi: 10.3389/fmicb.2019.02719

TABLE 3.

The fractional inhibitory concentration index (FICI) of the peptide/antibiotic combination against the MRSE 1208 strain.

FICI

Penicillin Ampicillin Ceftazidime Erythromycin Tetracycline
L11W 0.3121 0.2808 0.6248 0.2808 0.6248
L12W 0.2808 0.2574 0.6248 0.2808 0.5624
I1WL5W 0.2812 0.2578 0.5641 0.2812 0.2820
I4WL5W 0.1875 0.1562 0.5641 0.3124 0.6248

Synergy is defined as FICI ≤ 0.5, addition is defined as 0.5 < FICI ≤ 1.0, and indifference is defined as 1.0 < FICI ≤ 2.0 as indifference (Hollander et al., 1998; Yoon et al., 2004). Experiments were per formed in triplicate (n = 6).