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. 2019 Feb 21;104(10):1950–1961. doi: 10.3324/haematol.2018.214593

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Figure 1. — Dynamic changes of hematopoietic stem and progenitor cells with megakaryocyte potential in acute myeloid leukemia. (A) Left, refined model of native megakaryocytic differentiation from the canonical and non-canonical routes. Right, representative flow cytometric plots of hematopoietic stem and progenitor cell subpopulations involved in megakaryocytic differentiation. (B, C) Total numbers (B) and proportions (C) of LT-HSC, MPP2, PreMegE and MkP in normal hematopoietic cells in mice bone marrow at the indicated time points of AML. Data were normalized to the values in healthy controls and are presented as the percentage (B) or fold-increase (C) of controls. Four to five mice for each time point, three independent experiments. Error bars represent the standard error of mean. LT-HSC: longterm hematopoietic stem cells; LKS: Lin⁻/c-Kit⁺/Sca-1⁺; MPP: multipotent progenitor, PreMegE: pre-megakaryocytic-erythroid; MkP: megakaryocyte progenitor; MK: megakaryocyte; ST-HSC: short-term hematopoietic stem cells.