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. Author manuscript; available in PMC: 2019 Dec 3.
Published in final edited form as: Toxicol Appl Pharmacol. 2007 Jul 31;225(1):70–79. doi: 10.1016/j.taap.2007.07.009

Table 2.

Influence of PAMAM Dendrimer Type and Exposure Conditions on Lethality of Zebrafish Embryos

Dendrimer Time of Exposure (hpf) LC50 (μM) - 24 hpf LC50 (μM) - 72 hpf LC50 (μM) - 120 hpf
G3.5 6–120 --- --- ---
24–120 (+) chorion --- --- ---
24–120 (−) chorion --- --- ---
6–120 (−) chorion --- --- ---
G4.0 6–120 1.0 (0.9–1.2) 0.6 (0.5–0.6) 0.4 (0.3–0.4)
6–7.5 3.1 (1.5–18.9) 1.6 (0.7–33.4) 1.2 (0.7–3.0)
24–120 (+) chorion n/a 1.1 (0.8–1.3) 0.7 (0.6–0.8)
24–120 (−) chorion n/a 4.4 (3.5–5.7) 0.7 (0.6–0.8)
G3.5-RGD 6–120 --- --- ---
G4.0-RGD 6–120 --- --- 4.1*
*

slope not significantly different from zero, thus 95% confidence intervals could not be calculated.